Thanks, Joey. You've answered a lot of questions for me. I enjoyed your writing. Like you, I've been hell bent on recovering. I got sick about 2 years ago, at a time of stress and after a herniated disk had me on my back for a week. Things started going downhill from there, with lots of brainfog, sleep disturbance, fatigue. I went from running, climbing or working out every day to barely being able to stand for more than an hour. After all blood test results, MRIs, etc. came back normal I went ballistic, and it took me 49 days to get a diagnosis of POTS from a Harvard hospital. Step 1. Step 2, I started investigating alternative treatments and though did not think there was a viral connection involved, went on Dr. Enlander's hepapressin injections and Teitelbaum's multivitamin powder. After a year and little progress I went to Mayo to see Dr. Low, knons as the best POts and ANS doc out there. They confirmed the diagnosis, ruled out AcHR antibodies, and suggested Mestinon. But I held off on the Mestinon and at this point, tried something ridiculous, after reading of a British olympian (Anna Hemmings) who recovered using Reverse Therapy. I'm now 10 months into it and I'd say I'm back to about 65 percent of where I started. I can think straight most of the time. I've been running 20 minutes, every other day or so, and doing yoga 3 time a week. Reverse Therapy has been key: I went into it very skeptical, but have been impressed. I'm basically learning to reformat the way I think and process emotion. One of the things I realized was that I was being incredibly hard on myself, self criticial, self-driving when I got ill. I don't believe that is what got me sick. But it certainly increased my stress level, and the cortisol connection makes sense now. Anyhow, I'm going to get in touch with Mayo in the next few days. They did a research study on my cytokine levels when I was out there, but have not heard the results, and now I am curious. And of course I'm curious about XMVR. Frankly, I think I'd rather not have it. But that of course is irrelevant -- it's either there or not whatever my wishes on the matter. Ok. All for now. Thanks Joey for the inisightful write up. And thanks to all of you for a great forum.