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28-day Guanidinoacetic Acid Supplementation Improves Clinical Outcomes In Patients With CFS

Discussion in 'Latest ME/CFS Research' started by Dolphin, Sep 13, 2015.

  1. Dolphin

    Dolphin Senior Member

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    http://journals.lww.com/acsm-msse/F...Basic_Science_World_Congress_Poster__.16.aspx

     
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  2. Ema

    Ema Senior Member

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    And of course, the bodybuilding community is already on it...

    This article mentions that you have to take it with betaine since it will deplete methyl groups in the liver and cause homocysteine levels to rise over time.

    http://www.bodybuilding.com/fun/glycocyamine.htm
     
  3. Hip

    Hip Senior Member

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    The Wikipedia article for guanidinoacetic acid is here.

    According to this clinical trial of guanidinoacetic acid, this compound is a biochemical precursor of creatine.


    It does not look like it is available as a supplement as yet (this Google query searches for its various synonyms).
     
  4. Ema

    Ema Senior Member

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    Hip likes this.
  5. Ema

    Ema Senior Member

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  6. SOC

    SOC

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    I question whether these are really well-defined CFS patients. It seems more likely that they have found something that might help with generalized fatigue. This is no surprise since body-builders are already onto this supplement.

    I would like to think that this might help with our energy production problems, but I have no confidence at this point that they have demonstrated that it is effective, or even safe, for ME patients with PEM. I hope further research will use a better patient cohort and use a better measure of ME/CFS energy production problems than the MFI-20. A 2-day, even a 1-day, CPET would be good.
     
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