Discussion in 'Latest ME/CFS Research' started by Dolphin, Sep 13, 2015.
And of course, the bodybuilding community is already on it...
This article mentions that you have to take it with betaine since it will deplete methyl groups in the liver and cause homocysteine levels to rise over time.
The Wikipedia article for guanidinoacetic acid is here.
According to this clinical trial of guanidinoacetic acid, this compound is a biochemical precursor of creatine.
It does not look like it is available as a supplement as yet (this Google query searches for its various synonyms).
Supposedly it's in this protein drink but who can tell how much.
Or not. Other posts talk about how it was phased out in 2007.
But if you don't mind 200 mg of caffeine, there's a bit in here.
I question whether these are really well-defined CFS patients. It seems more likely that they have found something that might help with generalized fatigue. This is no surprise since body-builders are already onto this supplement.
I would like to think that this might help with our energy production problems, but I have no confidence at this point that they have demonstrated that it is effective, or even safe, for ME patients with PEM. I hope further research will use a better patient cohort and use a better measure of ME/CFS energy production problems than the MFI-20. A 2-day, even a 1-day, CPET would be good.
You can also try a Google Site Search
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