Steve, Peyronie's is associated with soft tissue calcification and excessive collagen production. It's very related to Dupuytren's contracture which is something my dad has. Soft tissue calcification can be caused by a vitamin K2 deficiency although most of the research has been in relation to the arteries. Vitamin K2 is very important for all sorts of things, especially the bones, the brain and testosterone. My dad also has bone erosion in his feet which is associated with inflammatory arthritis such as rheumatoid arthritis (RA). K2 has been shown to help with RA, so I'm going to buy Carlson's MK4 as it seems to have good feedback. I have no idea if it will actually work, this is just an educated guess. Further reading: www.westonaprice.org/fat-soluble-activators/x-factor-is-vitamin-k2 http://www.lef.org/magazine/mag2008...ne-And-Arterial-Health-With-Vitamin-K2_01.htm I've also been able to link excess collagen with low levels of glutathione and SAMe so the methylation supplements may help too.