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23andme test results

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Steve-22, Oct 29, 2012.

  1. Steve-22

    Steve-22

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    Balatonfüred
    Hello!

    Hope this is the right place to post it!
    I'm a 23 years old guy and have had never ending problems the last decade of my life.
    I have a double mutation for the PTSD gene and lost my Dad 8 years ago which I still couldn't accept.
    Talking about accepting things,I have severe perfectionism.S E V E R E.
    Not bed ridden like lots of CFS suffers but house bound.Get panics attack from door bell ringing.
    Paranoid.Constant flight or fight.
    My physical symptoms got worse after I took SSRI and developed bradycardia and heartburn after eating anything or drinking anything (I only drink tap water).
    Here is my genetic results:

    ACAT1 02,N/A,+-
    AHCY 19,N/A,--
    AHCY 02,N/A,--
    AHCY 01,N/A,--
    BHMT 08,N/A,++
    BHMT 02,N/A,+-
    BHMT 04,N/A,+-
    CBS,A360A,+-
    CBS,Y233Y (C699T),--
    COMT,H62H,++
    COMT,V158M,++
    COMT 61,P199P,--
    MTHFR,E429A (A1298C),+-
    MTHFR,A222V (C677T),--
    MTHFR 03,P39P,--
    MTR,A919G (A2756G),+-
    MTRR,A919G (A66G),++
    MTRR,K350A,--
    MTRR,R415T,--
    MTRR,H595Y,--
    MTRR 11,A664A,+-
    SHMT,C1420T,+-
    VDR,BSM/TAQ,--

    NOS1 rs3782206 C/T +/-
    NOS2 rs2297518 A/G +/-
    NOS2 rs2274894 G/T +/-
    NOS2 rs2248814 A/G +/-
    NOS3 rs1800783 A/T +/-
    NOS3 rs1800779 A/G +/-
    NOS3 rs2070744 C/T +/-
    NOS3 rs3918188 A/C +/-
    NOS3 rs7830 G/T +/-
    SOD2 rs2758331 A/C +/-
    SOD2 rs2855262 A/C +/-
    GAD1 rs3749034 A/G +/-
    GAD1 rs2241165 A/G +/-
    GAD1 rs2058725 C/T +/-
    GAD1 rs769407 C/G +/-
    GAD1 rs3791851 C/T +/-
    GAD1 rs3791850 A/G +/-

    Symptoms,everything I can think of (NOT IN CORRECT ORDER!):
    -eye tics (lessened over the years)
    -droopy eye lids
    -strong will
    -ankyloglossia (tongue tie)
    -deformed chest (breast bone and ribcage) on one side
    -scoliosis
    -chronic eye floaters
    -chronic tinnitus,ringing ears
    -visual snow
    -acted like if I wasn’t on the same level with my classmates,like I was 10 years younger than them brain-wise
    -mild incoordination
    -phobia of objects
    -dark circles under eyes,had it since childhood
    -mouth breathing
    -emotional instability
    -hand tremor,head tremor (becomes severe in social pressure,stress not got better)
    -loss of self-confidence,developed severe perfectionism
    -day dreaming,drowsiness
    -severe depression
    -severe anxiety
    -body very hairy (my back and chest and stomach was already hairy while my classmates started to develop armpit hair.but they DO HAVE FACIAL BEARD and I don’t)
    -severe phobia of dentists
    -crazy thinking,skizophrenic mind
    -racing thoughts
    -malloclusion
    -tongue thrust
    -anterior open bite
    -underdeveloped genital
    -symptoms of estrogen dominance,hypothyroidism,mercury poisoning,adrenal fatigue,brain damage and so on…
    -addictions,obsessed with things (smoking,computer,porn)
    -depersonalization
    -erectional disfunction
    -derealization
    -had to quit high school due to severe brain fog from SSRI use (still,can't finish it)
    -hypoglicemic reactions (worse after quitting smoking)
    -gained weight I couldn’t lose after starting SSRI drug
    -feminime hands and fingers and nail beds
    -white spots on nails every 5 years
    -awareness of heartbeat (constant,most uncomfortable symptom)
    -bradycardia
    -heartburn
    -OCD IS SEVERE……going crazy.SSRI induced.
    -shrinking genital
    -Peyronie's disease
    -sensitive to light (still,got worse not so long ago)
    -coarse hair
    -facial eczema
    -need for burping all day (lots of gases,30 secs after drinking)
    -insomnia
    -all my joints are cracking,popping (still,feeling like an 80 years old now for the past 4 years)
    -feeling like there’s something in my throat,sometimes hard to swallow
    -irritability
    -agression towards loved ones (still,getting really really bad...)
    -mood swings
    -puffy face
    -red scrotum and red dry glans
    -unable to make friends,communicate with other people (lacking of communcation skills)
    -heartbeat fails to go higher than 120-130 bpm during heavy exercise
    -UNABLE TO BUILD MUSCLE DESPITE GOOD DIET

    Please,guide me where to start.I was very athletic in my early teen years then PTSDs after PTSDs struck me and I'm here.My dream is to be able to build muscle and become athletic again.
    Please please help me!
     
  2. Marlène

    Marlène Senior Member

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    Edegem, Belgium
    Hello Steve

    welcome. Always sad to read young people are struck with health problems. So sorry to read about your dad.


    The first things that come up in my mind reading your symptoms are:

    Did your problems like OCD and perfectionism start overnight?
    Did you ever have a whiplash?
    Were you checked for lyme, toxoplasmosis, mycoplasma, chlamydia pneumonia,streps etc?
    Have you ever tried not eating gluten and milk for a few months so see if you feel better?
    How are your vit B12 and B6 levels?
    How are your thyroid TSH, T4, T3, reverseT3 levels and iodide levels? Were your antibodies to thyroid ever checked?
    If you respond badly to SSRI, were your adrenals checked?
    ...

    Best,

    Marlene
     
  3. Steve-22

    Steve-22

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    Sadly I think I've always had that addictive,ocd like personality.My thoughts were always obsessed with with cars and computer games but the SSRI made me physically obsessed,washing hands,objects have to be in position,touching chest and counting heartbeats...
    The perfectionism got worse with every single PTSD.Death of Dad,best friend moved to another city,thrown out of our own house with my Mother,bullied in school.
    I went to a private endochrinologist last year with the help of Xanax.She sent me for a blood test to the hospital.
    Due to watching my Dad die in front of me in the hospital,I have severe phobia of hospitals,doctors and anything medical related.The dental phobia is due to all the children crying and the painful procedure.
    As I was saying I went to the hospital to get the blood test done but I started to feel dizzy and I had a panic attack,nurses asking me if I'm alright? And ran out of the building like a mad man.

    I have been kicked in the head with football ~20 times in my life.3 of them were really nasty nose bleeds.
    Around age 6-8 my cousing has thrown a small rock at the back of my head,on the right side and then I've felt into a 4 feet deep construction pit,on my back.
    I have been bit by ticks 4-5 times in my life,never had a bull's eye rash,but the last time it was a bit red around the bite and I've managed to break it's body and leaving the head in.
    I'm on the gluten free diet but haven't noticed any benefit from it.
    I've quit the SSRI 1.5 years ago and suffering the prolonged effects.
    Swallowed mercury filling from tooth at around age 11.
    As far as I know because of the MTR,MTRR and MTHFR snps my B12 level was always deficient.
    Before I've forgot I had pneumonia in 2006.Had my chest X-rayed.The funny thing is that I had to always visit the doctor every year with frequent colds when I was a child.My treatment for the pneumonia lasted 2-3 months and it was pretty severe.After the treatment I've never had to visit the doctor with colds or fever again.
    Hopefuly this is enough information and thank you!
     
  4. merylg

    merylg Senior Member

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    Sydney, NSW, Australia
    Hi Steve,
    A lot of your symptoms are consistent with connective tissue disorders eg Marfan's, Loey-Dietz.
    Homocystinuria can mimic Marfan's too.
    Need to see a doctor who understands these disorders eg Rheumatologist and/or Geneticist.

    http://www.medicinenet.com/marfan_syndrome/article.htm
     
  5. maryb

    maryb iherb code TAK122

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    Steve - I think you need to have blood tests in order to find out what's going on, so one of the first steps I would say is to try to conquer your fear of hospitals, unless you can get your bloods done in a lab ( would you be as bad?)or home visit.
    You need to get back to the endocrinologist and sort out a way to do that.

    Have you thought about hypnotherapy for your OCD/fear of hospitals/dentist and possible other stuff? If you can find a really good therapist its well worth it, any recommendations from friends/family? Find one with a lot of experience and good track record.

    Sounds like you have a lot goiing on but the way I find to cope is to take one chunk at a time - I think the hormone side of it is important for you hence I would definitely keep on with the endocrinologist. Sometimes by treating one thing a lot of other things start to improve.
     
  6. Bonnielass

    Bonnielass

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    If it would help you to get the medical help you need and if you don't fancy hypnosis for the OCD/fear element (and it's a very natural state of being and quite pleasant) then NLP or EMDR are both great alternatives. As maryb says get a recommendation for an experienced practitioner.
     
  7. Steve-22

    Steve-22

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    An experienced practicioner told me to start taking Molybdenum and Yucca root,GABA,magnesium and vitamin C for the rest of my life and go on low thiol diet,to detoxify ammonia and sulphur and start taking calcium D glucurate for high estrogen and when my gut is healed then start taking Hydroxocobalamin with very small dose of methylfolate.
    I don't think an endocrinologist could help me with anything as far as I know my problem is with folic acid,B12 deficiency,malabsorbtion and heavy metal toxicity.
     
  8. nanonug

    nanonug Senior Member

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    Virginia, USA
    I am very sorry to hear about your many issues. I certainly don't have all the answers but there are a few things that caught my eye.

    Looking at these symptoms, it would appear to me that taking an SSRI is the wrong medicine for you. You have some of the classic ADHD symptoms which would suggest dopamine and/or norepinephrine deficits. In my opinion, going with a medication such as Wellbutrin or Strattera would be potentially much better.

    You also appear to have some stomach issues. My recommendation here is simply: get tested! I personally like the Metametrix GI Effects Complete Profile.

    One question: do your burps smell like rotten eggs?
     
  9. Steve-22

    Steve-22

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    Actually my breath stinks but not the burps.If I drink anything I will have to burp within 30 seconds.My Dad was burping all day.Died from pancreatic cancer @ age of 66.
    I wish I could do the stool test but can't finance it with a family labeling me lazy and hypochondriac. :(
     
  10. maryb

    maryb iherb code TAK122

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    And is that helping?
     
  11. Steve-22

    Steve-22

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    I need to wait till the order arrives and I can test the supplements one by one and will be more than happy to share if it does help me.
     
  12. nanonug

    nanonug Senior Member

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    If you address your ADHD symptoms, I think there's a good chance your perceived laziness would disappear...
     
  13. maryb

    maryb iherb code TAK122

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    Good luck with them hope they do help you.
     
  14. Marlène

    Marlène Senior Member

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    Edegem, Belgium
    [/QUOTE]
    Actually, adrenals are responsible for the output of epinephrine and norepinephrine.
    Did you know that gluten intolerance leads to exorphine overload and in some people to OCD?
    If you have exorphine overload, your dopamine level will be too low as well and you will need a trong stimulant (like drugs, games, ...) to feel normal/good.

    A good medicine is low dose naltrexone LDN. You have to be off gluten for 6 months ideally. It is a very cheap medicine. It stimulates the production of endorphine receptors. It is used as a treatment for ADHD, immune dysfunction, cancer, auto-immune disease, ... Endorphines are master regulators!

    You can read some more about it here:
    http://www.autismweb.com/forum/viewtopic.php?f=4&t=19846
    Kids with OCD are biggest responders to LDN

    http://www.pdazzler.com/wp-content/pdf/ldn_for_disease_prevention_quality_of_life.pdf

    www.ldnscience.com

    Or just look at the LDN topic here on the forum.
     
    merylg likes this.
  15. caledonia

    caledonia

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    Cincinnati, OH, USA
    Wow, you do have a lot of stuff going on!

    It looks like you did 23andme testing? They test so many SNPs I would think you would be able to see if you have any other genetic disorders like the Marfans.

    I had a similar bad experience with an SSRI. Your doctor and the drug companies will likely deny that SSRIs can cause these kinds of problems. I found out it's actually very common, and the symptoms can persist for a very long time afterwards after discontinuing (like a couple of years). Many of your symptoms sound like they're related to the SSRI use, such as sexual dysfunction and anxiety. I suggesting going to the Paxil Progress forum to learn more.

    These are supplements that helped me during SSRI withdrawal - magnesium, theanine (same as GABA), taurine (for heartbeats) - those are all calming - neuromedulla complex for noise and light sensitivity, and Relora to lower my cortisol which was extremely high.

    Xanax use can also cause rebound anxiety. I had a similar problem. You will need to slowly taper off. Same deal with an SSRI.

    For the heartburn try the baking soda burp test (google it). Your stomach acid may actually be low. In that case, take betaine hydrochloride to increase stomach acid. This will also help to absorb supplements and nutrients from food. On the other hand your stomach acid could be high due to high cortisol due to SSRI withdrawal. In that case, I would do Relora to lower the cortisol. I would suggest getting a cortisol saliva test to verify before taking something to lower cortisol.

    Since you have a history of tick bites, I would also get tested for tick-borne disease (assuming you have Lyme or other disease carrying ticks in your country).

    I would get tested for heavy metals, and chelate those out if you have them. Getting methylation restored should also help with getting metals out.

    For the PTSD and trauma, you can use EFT (emotional freedom technique). It's similar to the EMDR mentioned above, except it's free to learn and do yourself. This is a pretty good tutorial: http://eft.mercola.com/

    I wouldn't worry about building muscle right now. This is due to the CFS and if you follow a methylation protocol it should resolve. Weight loss may occur after you've been off the SSRI for a good while, or it may be blocked by the CFS/poor methylation.

    I will make another reply concentrating on your SNPs.
     
    Beyond likes this.
  16. caledonia

    caledonia

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    Cincinnati, OH, USA
    According to Yasko, the SNPs need to be addressed in a certain order which is SHMT/ACAT, CBS, MTHFR, MTR/MTRR, BHMT, MAO A, SUOX, NOS, VDR.

    You do have SHMT/ACAT, so I would start there. It sounds like your doc is having you start with CBS? Your CBS is only one mutation on the minor one, so I'm not sure if you would even need to address it? On the other hand, you also have BHMT which combines with CBS to make it worse, so maybe treating CBS will be necessary. Have you tried taking some liquid methylcobalamin drops under the tongue, and if so, what happened? If you get even more revved up and anxious and you don't get used to it, then I would treat for CBS.

    Look at the Heartfixer page for a good summary on all the methylation SNPs and how to treat them. http://www.heartfixer.com/AMRI-Nutrigenomics.htm

    One more post will follow.
     
    Marlène and Beyond like this.
  17. caledonia

    caledonia

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    Ok, there is so much stuff going on. Where to start?

    I suggest starting with reducing anxiety and restoring digestion. This will make your day to day existence more bearable, allow to you visit doctors and dentists, and give you a good base for methylation treatment.

    I would try EFT, EMDR, therapy, etc. Any non medication route for reducing anxiety. I would try calming supplements and check the cortisol levels. Lower the cortisol with Relora if it's high (should take about 8 weeks or so). If you're still on Xanax, possibly switch to clonazepam which is longer acting. Once you feel stable, then you can try very gradually tapering off.

    For the gut, a general program is a gluten free/dairy free diet, probiotics, digestive enzymes, and the betaine hydrochloride if your stomach acid is low. For heartburn/acid reflux, you can also try Da Vinci Labs G.I. Benefits to heal the gut. http://www.davincilabs.com/vitamins_supplements/gibenefits.php. It's l-glutamine plus a bunch of other stuff - sort of a super formula. You only need to take it for two or three months.

    Getting the gut in order is necessary to help utilize other supplements/nutrients you will be digesting in the future.
     
    Marlène and Beyond like this.
  18. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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    Murcia, Spain
    Caledonia you are really releasing a lot of good info! Have you tried this EFT yourself? I was advised on curezone to try it but sincerely never even tried to check it out since it looks like another self-energy healing and I believe I dont have the ability for that for now. You need to put your hand in certain parts? o_O
     
  19. Steve-22

    Steve-22

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    Wow thank you for the help everyone,especially Caledonia for the detailed information!
    I have updated my first post with more SNPs.

    Caledonia! You are right.The very first thing I must adress is gut health.
     
  20. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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    Murcia, Spain
    Hey at least Yucca Root will help with intestinal inflammation, will cut fermentation and acts as a prebiotic.
     

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