I finally got my 23andMe results back: +/+ : MTHFR C677T, VDR Taq, MAO-A R297R, MTR A2756G, MTRR A66G, SOD2 A16V, CYP2D6 S486T +/- : MTRR A664A, BHMT-02, BHMT-08, CBS A360A What I have interpreted, with help from the SNP Guide by @caledonia : First priority CBS A360A hetero with BHMT-02 & 08 hereto. Do I need to do a sulfur diet before methylation will work? The interpretation guide says "You only have to treat for CBS if it's expressed... Signs are having trouble with tolerating sulfur foods (MAYBE. I prefer non-sulfury veggies, but no obvious reaction), having trouble tolerating methyl supplements such as methylfolate (YES) and methylcobalmin no matter how small the dose. Classic symptoms are a stress/anxiety reaction (YES. I get GERD)... tight painful trapezius muscles (YES, that spot in particular hurt on methylfolate!) and so on. Second Priority: MTHFR C677T: This means I have 70-80% decreased functioning in folate conversion and metabolism. Probably need methylfolate supplementation. MAO-A R297R may explain my OCD. MTR and MTRR may explain why I am B12 deficient. CYP2D6 may explain why I never felt good taking the SSRI and tricyclics. --------- My main point of confusion is that my results suggest I need methylfolate (C667T), but when I took a methylfolate-containing multivitamin I experienced too much excitiotoxicity & insomnia. Is this because of CBS or another factor (too high Bs / minerals in the multivitamin or some other SNP genetic reaction)? If anyone else has any insight into my SNPs and any hidden story they tell, I would deeply appreciate it!