Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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23andme results no MTHFR mutations (Help)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by uriraha, Jul 4, 2014.

  1. uriraha


    I have finally done the 23andme test.

    This quite surprised me cause i was sure i had some mthfr issues but i don't.
    I suffer from chronic fatigue and depression which antidepressants do nothing for it.

    I found out i have some mtr/mtrr issues which as i read this mutation needs lots of methyl B12 which i already taking 1 mg daily.

    Should i add methyl folate for it? although i don't have any mthfr mutation? Cause i feel a bit anxious when taking the methyl B12 alone.

    I also have comt mutations should it be a problem? I understand people with comt mutations can't tolerate methyl groups very well.

    Is there anything i can do with the VDR/Taq mutation? i have vitamin d deficiency but i can't tolerate high doses of vitamin d (it cause me migraine) i can only tolerate 1000IU daily.
    Should i continue with the methyl B12 and methyl folate? or exchange it to hydroxy B12 base on my results.

    Any help will do for me i really need it


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    Last edited by a moderator: Jul 4, 2014
  2. UM MAN

    UM MAN Senior Member

    VDR Taq AA is not a mutation, it is normal.

    There are a lot of MAO-A homo-z people on here with depression and anxiety issues,
    but, so far there does not seem to be reified treatment.
    ramkishore likes this.
  3. Valentijn

    Valentijn Senior Member

    @uriraha - I don't see any problems in those results. If you want to look at additional MTRR and MTHFR mutations which might have an impact, there's lists at and

    Additionally, there's a downloadable program at which pulls out your very rare results. SNPs starting with "i" instead of "rs", and homozygous results can be especially interesting.

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