Hello - I recently discovered this site and am excited to find such a helpful and knowledgeable community. I've been researching natural ways to treat lifelong symptoms of depression, mood swings, anxiety and brain fog and am delving deeper into supplementation, methylation and genetic testing. I received my results back from 23andMe; this is a complicated journey but I am trying to figure out the initial steps and treatments for these genetic anomalies. This forum (and MTHFR.net) have been excellent resources so far, but I am at a bit of a loss of what to address first! And as to what combinations of gene defects can be tricky. Any insights or suggestions for what to look into would be greatly appreciated. My results are below; the ones that seem most concerning are MTHFR a1298c homo, MAO A R297R hetero, CBS 699T homo. COMT V158M rs4680 GG -/- COMT H62H rs4633 CC -/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CC -/- VDR Taq rs731236 AA +/+ MAO A R297R rs6323 GT +/- ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 GG -/- MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 GG +/+ MTR A2756G rs1805087 AG +/- MTRR A66G rs1801394 AA -/- MTRR H595Y not found n/a MTRR K350A rs162036 AA -/- MTRR R415T not found n/a MTRR A664A rs1802059 GG -/- BHMT-02 rs567754 CC -/- BHMT-04 not found n/a BHMT-08 rs651852 CC -/- AHCY-01 rs819147 TT -/- AHCY-02 not found n/a n/a AHCY-19 rs819171 TT -/- CBS C699T rs234706 AA +/+ CBS A360A rs1801181 -- no call CBS N212N not found n/a SHMT1 C1420T not found n/a n/a Symptoms: lifelong depression, anxiety and mood swings (worsened significantly for 1-2 weeks around my period/PMS-induced and debilitating at times). Brain fog, fatigue, low stamina; not all of the time, but more often than not and seem to correlate to my period, lack of sleep, stress, and occasionally caffeine consumption (16oz cup every day). Have tested for low iron previously. Tested low-ish for vitamin D, which I know is related to VDR?). I am 28/F, 120lbs. Current daily supplements: am/day: -fish oil (minami 850mg omega 3, 45mg omega 6, 35mg omega 9) - vit b12 (~125-250mg jarrow methylb12, which I believe is the proper form for MTHFR) - vit c (500mg+) - vit d (upped to 2,000 iu) - few times per week: Thorne Mediclear Plus powder- which seems to have a lot of helpful ingredients in general and the proper forms of b12 and folate as well as molybedum) pm/evening: - evening primose oil (500mg, sometimes 1,000mg around period) - zinc (50 mg as amino acid chelate) - probiotics (either udo's choice or pb8) - magnesium/calcium blend (Solaray ~700 mg mag citrate/oxide and cal citrate/hydroxide). I also take effexor 75mg daily and the occasional adderall xr 5mg (the latter makes me feel like a real person!). For diet, I focus on protein, fats, and am low-gluten, low-grain, low-sugar but have some slip ups. I eat greek yogurt every day and drink a lot of kombucha & mineral water. Thank you in advance for any insights and I look forward to speaking to more of you on this forum!