Hi all I posted here once before re some methylation queries and a few people were kind enough to help - I was advised to get 23andMe testing which I've now done and have my results courtesy of Genetic Genie. I've read a LOT of posts on here and the web generally (and my head now hurts) and just wondered if anyone could point me in the right direction or advise to help get properly to the bottom of things! I am UK-based and I don't think there are any specialist doctors coming up who specialise in this stuff at present. My results were as follows: Homozygous: MAO A R297R Heterozygous: COMT V158M COMT H62H VDR Bsm VDR Taq MTHFR A1298C MTRR A66G CBS C699T I knew about the MTHFR before from a separate test, and have been on a MethylB12, Methylfolate (Quatrefolic) and Biocare B-Plex (inc B6/P5P but no folic acid) supplement regime for a few months. Where I get confused is the interplay between the mutations and what’s actually agreed should be done. I also note that 23andme doesn’t cover SUOX or NOS but am running out of funds for any extra tests. CBS stuff seems really contentious – lots of stuff seems to cite Amy Yasko saying this is a massive deal (not sure if quite so much for heterozygous) and demands a low-protein diet and limited sulphur. But then I’ve seen various very well-reasoned arguments against this saying that it’s not nearly so significant and that’s NOT what should be done. Is there any conclusion on this – and is it co-dependent on other mutations? The Heartfixer site is pretty amazing but seems based on Yasko principles so I wondered if anyone had any differing views to point at. As far as I can see, my MTHFR and CBS stuff means I’ll have lots of ammonia kicking around, so I need molybdenum, carnitine and manganese and work on ‘BH4’. I can’t work out how the other stuff comes into play though – Heartfixer seems to suggest COMT mutations actually could be a good thing if you have BH4 problems I think. I have had previous issues with adrenals, anxiety, high histamine and tiredness which have all been enormously improved since taking the methylation supps and 2-3g of vitamin C per day (have been on vit C for several years). Any help very much appreciated indeed if anyone has any idea of the interplay/seriousness of the above, what to do or where else to look. Thanks again.