23andme Results Are In!!!

[Changexpert]

As expected, I am Mao +/+... ARGH
It looks like my detox pathway is pretty decent. I have a couple of specific questions.

1. Are there any supplements I need to watch out for? Is combination of Mao ++, COMT +/-, VDR +/- and CBS360A ++ prone to ammonia build up?
2. Is mb12 a poison or a treasure for me?
3. Is taking phosphatidylserine a good idea since I have heterozygous BHMT?
4. Is there anyway I can find SUOX mutation status?
5. What other things should I watch out for with my profile?
6. What can I do about not genotyped data?

I would sincerely appreciate anyone's input. @Valentijn as well

 

[Sherpa]

Yep...watch out and make sure your B2 levels are adequate. This will help MAO work. Otherwise, nice genes... Could be much worse.

 

[Valentijn]

1. Are there any supplements I need to watch out for? Is combination of Mao ++, COMT +/-, VDR +/- and CBS360A ++ prone to ammonia build up?

Supposedly you might tolerate hydroxoB12 better than methylB12. But MAOA is a rough guideline at best, and COMT +/- and VDR +/- shouldn't be having any impact.

2. Is mb12 a poison or a treasure for me?

Neither: it's a vitamin. It might help a bit with some problems. It's not a cure for anything except B12 deficiency.

3. Is taking phosphatidylserine a good idea since I have heterozygous BHMT?

BHMT +/- doesn't have an impact.

4. Is there anyway I can find SUOX mutation status?

If you sign in at your 23andMe page via https://www.23andme.com/you/explorer/gene/?gene_name=SUOX you can see your SUOX results. The common result for rs705703 is CC, though there's no indication that T causes any problems. The normal results for i5000977 and i5000976 are both AA.

5. What other things should I watch out for with my profile?

Heterozygous MTRR mutations don't have an impact, but if you have another +/- missense mutation, it could slow down the functioning of the gene a bit. The other missense mutations are listed at http://forums.phoenixrising.me/index.php?threads/interesting-mtrr-variations.24551/ and they're the underlined ones.

6. What can I do about not genotyped data?

Nothing really, but the "not genotyped" stuff on the Yasko list isn't particularly important anyhow.