I have had Candida issues for about 13 years. I have been dealing with heavy metal overload, Lyme, Bartonella, and depression for about 8 years. My main symptoms have been hand/wrist pain (esp. tendonitis), arm, shoulder, neck, and low back pain. My pain was much better for a few years while I was exercising, but stopped about 2 years ago (or was it one year?) for various reasons. I also have had anxiety and phobias all my life. No panic attacks. Some memory issues (word search) at times over the last couple of years. I have been on a Paleo diet for the last 18 mos. or so. It helps with my Candida. Also, I was muscle tested and found to be allergic to dairy, gluten, soy, and corn. Two other muscle testers have disagreed with this, but so far I have scrupulously avoided these foods. The one time I made an exception to the diet was when I had some dairy one day earlier this summer, and I had deep shifting muscle pain, plus knee pain, for several weeks after that. I also had increased depression on wheat a few years ago. So I suppose there is some truth to the original muscle testing. My doctor ran a Methylation Profile on me thru Doctor's Data about 18 months ago. The only abnormal result was SAMe, which was low. My doc wanted me to supplement SAMe but I had tried both SAMe and another supplement for depression some years ago and felt very rageful on one of them, but can't remember which one! So I am hesitant to try the SAMe again, in case it was the one that caused the rage. Also, I am reading that some docs don't recommend SAMe as a supplement, they recommend fixing methylation. I got my 23andme done earlier this year, but don't really understand a lot of it. Here are my results, a la Genetic Genie: +/+ = COMT V158M, H62H, VDR taq, MAO A R297R, MTHFR A1298C +/- = COMT P199P, MTR A2756G, MTRR K350A, AHCY 01,19, CBS C699T, A360A My ND looked at these results and had me start on hydB12 (Perque), and I have been taking 1/4 tab (500 mg) daily since mid May. I was already having some degree of fatigue at that time, and the Perque did not change anything there. She also wanted me on Molybdenum, which I have tried off and on in small amounts but it seems to make me tired sometimes or to cause some chest pressure. I also started 1 capsule per day of B-Minus (10 mg thiamin, 20 mg R5P, 180 mg Niacin, 20 mg P5P, 150 mg Pantothenic acid, plus Biotin (I take tons of biotin due to recent hair loss)). Maybe I should cut this back to 1/2 capsule once or twice daily? I was supposed to also add BH2, SAMe, creatine powder, and MTHF. Then I am supposed to add mB12. Due to various other health issues that came up this summer, and my usual general state of overwhelm, I haven't added any of these. In the last 3 weeks, my energy has really gone down. I feel fine for a while, then I am fatigued for some hours. I drove 90 mins and was exhausted -- this is not usual for me. I have been having insomnia all summer to some degree but it is worse now. I do take naps, long ones if needed. At the start of the summer, my doc noted that my liver enzymes are up slightly. I feel like I am not detoxing enough but right now I just can't get myself to sauna or take baths. I am not helping myself very well!! I have had a bunch of other health issues come up this summer, especially elevated submandibular lymph nodes, hair loss (over 50% of my hair), moderate to high scalp tenderness, scalp seborrhea/itching (I believe this is unrelated to the hair loss because the seborrhea is localized). My doc did some testing and put me on an adrenal glandular supplement, thyroid glandular supplement, and Progesterone. The latter seems to be helping with the hair loss. I am planning on getting my amalgams out soon, though now I am worried about how well I will do with detoxing the sedatives (I am a very nervous patient). I do feel the dentist is taking all the precautions to keep my Mercury load down. Once the amalgams are out, I am supposed to start chelation. My Lead is especially high. A few days ago I quit the B12, and, though this seemed to increase my energy temporarily, yesterday I was wiped out again. I thought maybe my fatigue might have been caused by being on the wrong B12. Also, I received no instructions on increasing my potassium intake when I started the B12. I am realizing I need to take MTHF with the B12 (though seem to not feel well on the MTHF), also maybe need to add some K+, though not sure how much, and am wondering about other cofactors. Should I switch to a different B12? Do I need to tough it out with the Molybdedenum and MTHF even though it makes me tired?