I just ran my 23andme raw data through Genetic Genie and got the following results. Any insight and advise would be much appreciated! Methylation: COMT V158M rs4680 AG +/- COMT H62H rs4633 CT +/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CT +/- VDR Taq rs731236 AG +/- MAO-A R297R rs6323 TT +/+ ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 AG +/- MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 TT -/- MTR A2756G rs1805087 AG +/- MTRR A66G rs1801394 AG +/- MTRR H595Y rs10380 CC -/- MTRR K350A rs162036 AA -/- MTRR R415T rs2287780 CC -/- MTRR A664A rs1802059 GG -/- BHMT-02 rs567754 CC -/- BHMT-04 rs617219 AA -/- BHMT-08 rs651852 CT +/- AHCY-01 rs819147 TT -/- AHCY-02 rs819134 AA -/- AHCY-19 rs819171 TT -/- CBS C699T rs234706 AA +/+ Detox: Gene & Variation rsID Alleles Result CYP1A1*2C A4889G rs1048943 TT -/- CYP1A1 m3 T3205C rs4986883 TT -/- CYP1A1 C2453A rs1799814 GG -/- CYP1A2 164A>C rs762551 AC +/- CYP1B1 L432V rs1056836 CG +/- CYP1B1 N453S rs1800440 CT +/- CYP1B1 R48G rs10012 GG -/- CYP2A6*2 1799T>A rs1801272 AA -/- CYP2A6*20 rs28399444 II -/- CYP2C9*2 C430T rs1799853 CC -/- CYP2C9*3 A1075C rs1057910 AC +/- CYP2C19*17 rs12248560 CT +/- CYP2D6 S486T rs1135840 GG +/+ CYP2D6 100C>T rs1065852 AG +/- CYP2D6 2850C>T rs16947 AG +/- CYP2E1*1B 9896C>G rs2070676 CC -/- CYP2E1*1B 10023G>A rs55897648 GG -/- CYP2E1*4 4768G>A rs6413419 GG -/- CYP3A4*1B rs2740574 CT +/- CYP3A4*2 S222P rs55785340 AA -/- CYP3A4*3 M445T rs4986910 AA -/- CYP3A4*16 T185S rs12721627 GG -/- GSTP1 I105V rs1695 AG +/- GSTP1 A114V rs1138272 CT +/- SOD2 A16V rs4880 AA -/- NAT1 R187Q rs4986782 GG -/- NAT1 R64W rs1805158 CC -/- NAT2 I114T rs1801280 CT +/- NAT2 R197Q rs1799930 AG +/- NAT2 G286E rs1799931 GG -/- NAT2 R64Q rs1801279 GG -/- NAT2 K268R rs1208 AG +/- Gene Result GSTT1 Absent* * It is likely that you are missing this gene and have a deletion. However, since this type of testing isn't technically designed to detect deletions, it isn't with 100% certainty. Also previous genetic testing through Genova Diagnostics shows: GSTM1 Absent Other SNPs from Genova matched Genetic Genie except that Genova showed for me: SOD2 A16V +/+ And that I have polymorphisms in CYP1B1, CYP2C9, and CYP3A4 Thoughts and advice are much appreciated! Brent -------------------------------------- I also googled GSTT1 and it said this: "This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione." http://en.wikipedia.org/wiki/GSTT1 I may be way off, but this make me wonder if this is why I had a bad withdrawal from Klonopin, which I'm now back on (to keep away sensitivity to light and sound, which I didn't have before taking Klonopin, even though I had fatigue). Anyway, 2 genes relating to glutathione are possibly absent.