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23andme pricing change

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by roxie60, May 13, 2012.

  1. roxie60

    roxie60 Senior Member

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    Central Illinois, USA
    Well I was about to select 23and me but looklike in last day or so the price has gone up to $299 w/o subscription. It was $207 with subscription a couple days ago. Now will cost me $100 more. Bummed. Or was that $207 plus $9 per month for yrs subscription, if so then price is same. I don't know too tired, did they increase price $93?
  2. nanonug

    nanonug Senior Member

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    You are right, prices just went up! And now, they don't even have the monthly subscription option. The only option I get right now is $299.
  3. SickOfSickness

    SickOfSickness Senior Member

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    If you're willing to wait, I bet they would have a sale by the end of the year. Their sales may not be as good as past sales, but past ones were a very good discount off regular price.
  4. roxie60

    roxie60 Senior Member

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    Cant believe my luck, I was ready today to order (I was still trying to figure out allthe tests and see which ones my Dr would order). I dont think I can wait, right now I have to wait to see Drs and get approval for tests I think would allow me to know where I stand but it takes forever, the Metametrix test wont be ordered until end of June (cant see Dr until 6/20), still trying to convince my Dr to allow the Methyl Pathways test (does tat include Amino Acids or is that a separate test?) and my Dr does approve the Yasko test (I dont really need her approval but she is the only Dr that at least listens to me) but that is pricey. So now the tests I am consider ing are:

    1. Methylation Pathways ($190) - no Dr approval yet
    2. Yasko Nutrinomics ($499 + S&H) - My DR would prefer I do this one
    3. Metametrix GI ($??) - Dr see 6/20 favors this test
    4. 23andme ($299) - no Dr approval required

    Any others needed to verify CFS and determine course of action to resolve symps? Cant wait cause need answers, dont want to lose job and employer wants update by 5/22. Cant get any results back by then but hopefully Dr will support a little more time so I can get at least the 23andme results back. My IgG test result should arrive this week but as many have warned me here I should not get my hopes up (I'm use to that).
  5. nanonug

    nanonug Senior Member

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    The Metametrix GI Effects Complete Profile cost me almost 400 bucks. Neither doctors nor insurance were involved. Had to wait just a bit over two weeks to get my results back after the lab received my sample. I bought the kit from YourWayToWellness.com. In my case, I was very happy with this test because it found something of significance. Unfortunately, there are no guarantees that this or any other test will be able to do the same for you. My philosophy in this case is to continue to look for plausible causes and test for them until I get a "hit".

    By the way, at this point I believe that genetic testing is the least useful. This is based on my "gut feeling" (pun intended) that a vast majority of CFS cases are somehow related to the gut (infection/overgrowth/dysbiosis/etc). However, I am also convinced that this "rule" of mine has many exceptions so take it with a grain of salt, please.
  6. roxie60

    roxie60 Senior Member

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    thx for your input nanonug
  7. madietodd

    madietodd Senior Member

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    Thanks for the link, nanong. This kit costs almost $100 more from directlabs.
  8. roxie60

    roxie60 Senior Member

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    can someone who has taken 23andme tell me if the following are included in results

    GSTM1
    SOD
    HMNT
    DAO
    QDPR

    THX
  9. nanonug

    nanonug Senior Member

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    All those genes show up on 23andme. However, not all SNP's will be available. For example, an important SNP for HNMT is not available on 23andme (I forget which one now). Do specifically know which SNP's you need?
  10. globalpilot

    globalpilot Senior Member

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    Ontario
    Me too. My test found quite low secretory IgA. I think that might be one of my main "hits". It sure would explain my gut symptoms. It also eliminated some other possibilites too , such as pancreas function.
  11. nanonug

    nanonug Senior Member

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    Have you tried supplementing with Saccharomyces boulardii? Should help bring your sIgA levels back up...
  12. globalpilot

    globalpilot Senior Member

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    Ontario
    I haven't done anything yet. but I'm going to do colostrum first and then maybe s boulardii.
  13. Jack Ruane

    Jack Ruane

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    Ran across your post and thought I could add a few points:

    - 23andme is running a sale through Sunday 8/22/12 for $50 bucks off with Discount code VMQ6KG

    -Although some genetic tests like Yasko Methylation and DetoxiGenomics are great because they hit all the key SNPs for a particular function, 23andme hits 1 million points of data that I have found extremely useful. I have picked up many important things from them. The frustrating thing is that they seem to only cover 75% of SNPs in a given area. It is useful because you can get a sense if you have mutations in a given area. You could follow up with other testing.

    - 23andme provides you with the raw data for all 1 million points which you can download. This is useful as they also offer 3rd party apps that read and use that data. Promethease is an add-on that provides an alternative analysis and report to 23andme that I have pulled some critical gems from. There is also a firefox plugin that highlights any SNPs in a web page and automattically shows your data in a box so you do not need to look it up. This is helpful when reading a research study. Cool stuff.

    - Regarding the genes you mentioned, 23and me looks at the following:
    GSTM1 - Some SNPs
    SOD - A good number of SNPs
    HMNT - No idea yet
    DAO -No idea yet
    QDPR - No idea yet


    P450 Cytochrome Genes Only a select few are listed here Risk Allele as reported on (+) strand

    CYP1A1 rs4646903 CYP1A1*2A T3801C +C/-T C Not tested by 23andme
    CYP1A1 Unknown CYP1A1*2B A2455G +G/-A G
    CYP1A1 rs1048943 CYP1A1*2C A4889G +C/-T C
    CYP1A1 rs4986883 CYP1A1 m3 T3205C +C/-T C
    CYP1A1 rs1799814 CYP1A1*4 C2453A +G/-T G
    CYP1B1 rs1056836 L432V
    +G/-C G
    CYP1B1 rs1800440 N453S +C/-T C
    CYP1B1 rs10012 R48G +C/-G C
    CYP1B1 rs1056827 A119S +T/-G T Not tested by 23andme
    CYP1B1 rs1056837 D449D +T/-C T Not tested by 23andme

    Other Detoxification and Methylation SNP's Risk Allele (+) Source of info

    MTHFR rs2274976 G1793A +T/-C T Found in study
    GSTM3 -
    GSTP1 rs1695 I105V +G/-A G Not tested by Yasko On the Detoxi Genomics Profile
    GSTP1 rs1138272 A114V +T/-C T Not tested by Yasko On the Detoxi Genomics Profile
    SOD1 Unknown G93A +A/-G A Not tested by Yasko On the Detoxi Genomics Profile
    SOD1 Unknown A4V - Not tested by Yasko On the Detoxi Genomics Profile
    SOD2 rs4880 A16V +G/-A G Not tested by Yasko On the Detoxi Genomics Profile
    NAT1 rs4986782 A560G? (R187Q) +A/-G A Not tested by Yasko On the Detoxi Genomics Profile
    NAT1 Unsure rs1805158(?) C190T (R64W) +T/-C T Not tested by Yasko On the Detoxi Genomics Profile
    NAT2 rs1801280 T341C (I114T) +C/-T C Not tested by Yasko On the Detoxi Genomics Profile
    NAT2 rs1799930 G590A (R197Q) +A/-G A Not tested by Yasko On the Detoxi Genomics Profile
    NAT2 rs1799931 G857A (G286E) +A/-G A Not tested by Yasko On the Detoxi Genomics Profile
    NAT2 rs1801279 G191A (R64Q) +A/-G A Not tested by Yasko On the Detoxi Genomics Profile
    NAT2 rs1208 A803G (K268R) +G/-A G Not tested by Yasko On the Detoxi Genomics Profile
    CTH rs1021737 S4031I +T/-G T Not tested by Yasko

    In 23andme format Risk Allele as reported on (+) strand
    ACE rs1799752 Del 16 +D/-I D
    CBS rs1801181 A360A +A/-G A
    CBS rs234706 C699T +A/-G A
    CBS rs2298758 N212N +A/-G A
    COMT rs4633 H62H +T/-C T
    COMT rs4680 V158M +A/-G A
    COMT rs4818 L136L +C/-G C
    COMT rs769224 -61 P199P +A/-G A
    MOA A rs6323 R297R +T/-G T
    MTHFR rs1801133 C677T +A/-G A
    MTHFR 03 rs2066470 P39P +A/-G A
    MTHFR rs1801131 A1298C +G/-T G
    MTR rs1805087 A2756G +G/-A G
    MTRR rs1801394 A66G +G/-A G
    MTRR rs10380 H595Y +T/-C T
    MTRR rs162036 K350A +G/-A G
    MTRR rs2287780 R415T +T/-C T
    MTRR rs2303080 S257T +T/G- T
    MTRR-11 rs1802059 A664A +A/-G A
    NOS 3 rs1799983 D298E +T/-G T
    SUOX Unknown S370S +C/-T C
    SUOX rs7297662 A628G +G/-A G
    VDR rs1544410 Bsm/Taq +T/-C T
    VDR rs10735810 Fok I +T/-C T
    ACAT1-02 rs3741049 +A/-G A
    AHCY-01 rs819147 +C/-T C
    AHCY-02 rs819134 +G/-A G
    AHCY-19 rs819171 +C/-T C
    BHMT-01 rs585800 +T/-A T
    BHMT-02 rs567754 +T/-C T
    BHMT-04 rs617219 +C/-A C
    BHMT-08 rs651852 +T/-C T
    SHMT1 rs1979277 C1420T +A/-G
    A



    Hope this helps
    fozzaw likes this.
  14. triffid113

    triffid113 Day of the Square Peg

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    Michigan
    Just a note, but I gave my Dad this boulardi to help him get rid of C.Diffs. It causes EXPLOSIVE diarrhea (an EXTREME worsening of symptoms). If you check this out on Wiki, you will see that they say it CANNOT BE GIVEN to immunocompromised people as it causes a fatal yeast infection. References point to a hospital in England that was giving this for C.Diffs and showed that it caused the death of many infirm patients whose death was proven to be caused by yeast infection.

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