The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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23andme Dopamine receptors mutations

Discussion in 'Genetic Testing and SNPs' started by Jlc26, Apr 7, 2015.

  1. Jlc26

    Jlc26

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    Does anyone know what supplements might help with DRD2, DRD3, DDC, and DBH polymorphisms? I have many homozygous snps for all of these from mthfrsupport. I have had anxiety, depression, and CNS problems for years. How might these polymorphisms be contributing?
     
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  2. renerdrat

    renerdrat Every teardrop is a waterfall

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    Temecula
    Not sure but I have a few mutations that result in very low dopamine. Super increased risk for schizophrenia. What kind of cns problems do you have, have you used anything that has helped? I just started learning about mthfr
     
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  3. Valentijn

    Valentijn Senior Member

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    Which SNPs do you believe are causing a "super increased risk for schizophrenia" and what's the basis for that belief?

    Most SNPs have very small correlations with illness. Such as a 2x greater risk of getting a disease present in 0.1% of the population, for example. Which results in a 0.2% risk, and isn't exactly overwhelming.
     
  4. pogoman

    pogoman Senior Member

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    for what its worth I have close to a dozen different DRD homozygous red SNPs from Sterlings App and I don't believe I have those issues beyond the ordinary.
    I have about 28 red SNPs total in the neurotransmitter pathway section so it may be that its common for people to have many of these homozygous SNPs.
     
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  5. caledonia

    caledonia

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    Cincinnati, OH, USA
    This is the problem with Sterling's App - there are zillions of SNPs, but little info about what, if anything, to do about them.

    That being said, it seems to me that if the dopamine receptors are not working well, you would want to increase dopamine in some way.

    Also, anxiety, depression and CNS symptoms can be caused by many things other than dopamine receptor issues, or even dopamine issues in general.

    Hetero SNPs can also be contributors, as well as environmental factors.
     
    Gondwanaland likes this.
  6. ppodhajski

    ppodhajski

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    Chapel Hill, NC
    Yes, I agree Caledonia that low dopamine receptor SNPS mean you need more dopamine. Well, sometimes. :)

    We really need to see all the SNPs in the catecholamine pathway to make that determination.

    @Jllc26

    Do you have a promethease report?

    DDC uses P5P (B6) as a cofactor
    http://www.uniprot.org/uniprot/P20711

    DBH might use several but I think copper in the limiting factor here (But stimulating this would decrease dopamine)
    http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58442

    If you have anxiety I would doubt you need more Dopamine. What do your GAD1, MAOA, MAOB and COMT look like? I suffered from disabling anxiety and panic attacks, and CNS issues up until six month ago when I found out how to treat these SNPs.

    Can you post your sterlings app results?
     
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  7. renerdrat

    renerdrat Every teardrop is a waterfall

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    Temecula
    i dont remember the exact snps but on my promethius report or whatever that website is called it said i was a lot more at risk
     
    oceiv likes this.
  8. Valentijn

    Valentijn Senior Member

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    Those increases are usually quite tiny.
     

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