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23andme Dopamine receptors mutations

Messages
14
Does anyone know what supplements might help with DRD2, DRD3, DDC, and DBH polymorphisms? I have many homozygous snps for all of these from mthfrsupport. I have had anxiety, depression, and CNS problems for years. How might these polymorphisms be contributing?
 

renerdrat

Every teardrop is a waterfall
Messages
46
Location
Temecula
Not sure but I have a few mutations that result in very low dopamine. Super increased risk for schizophrenia. What kind of cns problems do you have, have you used anything that has helped? I just started learning about mthfr
 
Messages
15,786
Not sure but I have a few mutations that result in very low dopamine. Super increased risk for schizophrenia. What kind of cns problems do you have, have you used anything that has helped? I just started learning about mthfr
Which SNPs do you believe are causing a "super increased risk for schizophrenia" and what's the basis for that belief?

Most SNPs have very small correlations with illness. Such as a 2x greater risk of getting a disease present in 0.1% of the population, for example. Which results in a 0.2% risk, and isn't exactly overwhelming.
 

pogoman

Senior Member
Messages
292
Does anyone know what supplements might help with DRD2, DRD3, DDC, and DBH polymorphisms? I have many homozygous snps for all of these from mthfrsupport. I have had anxiety, depression, and CNS problems for years. How might these polymorphisms be contributing?

for what its worth I have close to a dozen different DRD homozygous red SNPs from Sterlings App and I don't believe I have those issues beyond the ordinary.
I have about 28 red SNPs total in the neurotransmitter pathway section so it may be that its common for people to have many of these homozygous SNPs.
 

caledonia

Senior Member
Does anyone know what supplements might help with DRD2, DRD3, DDC, and DBH polymorphisms? I have many homozygous snps for all of these from mthfrsupport. I have had anxiety, depression, and CNS problems for years. How might these polymorphisms be contributing?

This is the problem with Sterling's App - there are zillions of SNPs, but little info about what, if anything, to do about them.

That being said, it seems to me that if the dopamine receptors are not working well, you would want to increase dopamine in some way.

Also, anxiety, depression and CNS symptoms can be caused by many things other than dopamine receptor issues, or even dopamine issues in general.

Hetero SNPs can also be contributors, as well as environmental factors.
 

ppodhajski

Senior Member
Messages
243
Location
Chapel Hill, NC
This is the problem with Sterling's App - there are zillions of SNPs, but little info about what, if anything, to do about them.

That being said, it seems to me that if the dopamine receptors are not working well, you would want to increase dopamine in some way.

Also, anxiety, depression and CNS symptoms can be caused by many things other than dopamine receptor issues, or even dopamine issues in general.

Hetero SNPs can also be contributors, as well as environmental factors.

Yes, I agree Caledonia that low dopamine receptor SNPS mean you need more dopamine. Well, sometimes. :)

We really need to see all the SNPs in the catecholamine pathway to make that determination.

@Jllc26

Do you have a promethease report?

DDC uses P5P (B6) as a cofactor
http://www.uniprot.org/uniprot/P20711

DBH might use several but I think copper in the limiting factor here (But stimulating this would decrease dopamine)
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58442

If you have anxiety I would doubt you need more Dopamine. What do your GAD1, MAOA, MAOB and COMT look like? I suffered from disabling anxiety and panic attacks, and CNS issues up until six month ago when I found out how to treat these SNPs.

Can you post your sterlings app results?
 

renerdrat

Every teardrop is a waterfall
Messages
46
Location
Temecula
Which SNPs do you believe are causing a "super increased risk for schizophrenia" and what's the basis for that belief?

Most SNPs have very small correlations with illness. Such as a 2x greater risk of getting a disease present in 0.1% of the population, for example. Which results in a 0.2% risk, and isn't exactly overwhelming.
i dont remember the exact snps but on my promethius report or whatever that website is called it said i was a lot more at risk
 
Messages
47
Yes, I agree Caledonia that low dopamine receptor SNPS mean you need more dopamine. Well, sometimes. :)

We really need to see all the SNPs in the catecholamine pathway to make that determination.

@Jllc26

Do you have a promethease report?

DDC uses P5P (B6) as a cofactor
http://www.uniprot.org/uniprot/P20711

DBH might use several but I think copper in the limiting factor here (But stimulating this would decrease dopamine)
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58442

If you have anxiety I would doubt you need more Dopamine. What do your GAD1, MAOA, MAOB and COMT look like? I suffered from disabling anxiety and panic attacks, and CNS issues up until six month ago when I found out how to treat these SNPs.

Can you post your sterlings app results?[/Q
@a
Yes, I agree Caledonia that low dopamine receptor SNPS mean you need more dopamine. Well, sometimes. :)

We really need to see all the SNPs in the catecholamine pathway to make that determination.

@Jllc26

Do you have a promethease report?

DDC uses P5P (B6) as a cofactor
http://www.uniprot.org/uniprot/P20711

DBH might use several but I think copper in the limiting factor here (But stimulating this would decrease dopamine)
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58442

If you have anxiety I would doubt you need more Dopamine. What do your GAD1, MAOA, MAOB and COMT look like? I suffered from disabling anxiety and panic attacks, and CNS issues up until six month ago when I found out how to treat these SNPs.

Can you post your sterlings app results?

@ppodhajski I have several mutations in SLC6A4, HTR2A, DDC Enzymes? I will be interested in knowing on how you resolved your issues? Thanks