Looking Ahead to Change: Little by Little
I don't make New Year's Resolutions. I don't think I ever really did, but the last decade or two would have been enough to stifle that impulse. I've just been too aware that I don't have that much control over what happens in my life.
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23andme & Chronic insomnia and family history of psychiatric/CNS disorders

Discussion in 'Genetic Testing and SNPs' started by xptriado, Feb 12, 2014.

  1. EMilo

    EMilo Elizabethmilo.com

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    Seattle, WA
    @xptriado Did you ever get the insulin tolerance test? I would love to know your experience.
     
  2. xptriado

    xptriado Senior Member

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    @EMilo i didnt get the test. i figured the chance i had something wrong there was very slim and i didnt pursue this avenue any further. my exams didnt point me in this direction

    im coming here to say somethingpositive, i'm much better than i was when I originally posted this.

    I followed some recomnedations form jack kruse and I got good improvements from it. i am still going to try other things like nicotine patch and methylene blue, possibly.

    i tried countless medications.

    I settled for the moment on the following, which I take at least once a week to recover sleep, thus helping break anxiety cycle.

    Oxazepam 7.5mg
    Alprazolam 0.25mg
    Melatonin

    The synergy works great for me. The oxazepam is really great because of its delayed peak time of 4 hours... melatonin alsogives a better sleep in the presence of the benzos, while preventing tolerance build up..or at least i havent felt it yet. i also use earplugs because I have problems with noises waking me up a lot. so I bought some amazing aluminium earplugs from a kickstarter project, company called ISOLATE. if you have this issue i cant recommned it highly enough.

    I discovered I have misophonia...or better said, I discovered my noise sensitivity has a medical name nowadays.

    I am going to try a medication called vortioxetine, possibly.

    I am investigating a few avenues now:
    - mitochondria
    - depression, through 5ht3a or through nicotinic acetylcholine receptors
    - vagus nerve stimulation.
    - p glycoprotein. this is probably the reason why dexametasone fixed me.

    I dont come here often anymore, as I dont think my issue is ME CFS anymore (so careful if you decide to try something which worked for me). I hope you guys who helped me around here are also feeling better
     
    merylg and actup like this.
  3. Thewonders92

    Thewonders92

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    So the treatment for low D2 receptors, or lack of expression is to take high dose d2 antagonists?
     
  4. xptriado

    xptriado Senior Member

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    hi, lets put this on hold for a bit. its just a patent, which doesnt mean much withouth backing clinical trials. high dosage antipsychotic isnt what we want. but i will be adding low dose risperidone soon enough for its 5ht2a and D2 blocking properties, for sleep.0.5mg is how high ill go

    I am reporting on a signiifcant finding.

    after the dexametasone positive experience i started wonedering why i reacted like that. i cant just take dexamethasone so maybe i needed to fix whatever was broken. i realized one such option was to fix a glucocorticoid receptor issue.i realized such issues are part of mood disorders. so i got my self trying antidepressives and finally ive hit upon a posssibly good one. vortioxetine. this pill gave me energy back. i suspect this energy is tied to a resensitization of the glucocorticoid receptors. i have to add, i didnt feel depressed or at least not normal depressive symptoms but i still took the plunge to see what would happen and how it would affect this HPA axis and sleep.

    Now It seems this has changed my reaction to sleeping pills. they seem to work much better however im still experimenting but they actually seem to always work now, instead of once in while, and rest of the time being unhelpful/prejudicial.

    i also ahve a vague idea of this behaviour happening after strenous exercise at night but due to the nature of my problem i cant do that often. so i was wondering if the key here for the sleeping pills to work better really is having a higher HPA, and if anyone who says sleeping pills dont work very well or leave you with worse sleep than withouh them...maybe try to take HC just before bed together with the sleeping pill and see if there is a difference.

    Im talking about benzodiazepines. clonazepam, a very bad sleeping pill, has been now helping me sleep wonderfully instead of making me feel dead for the day the next day, without any obivous improvemen in sleep, most of the times i used it. and many times making things worse. once in a while things would fall in place and it would wokr,....about once in a blue moon. and the dosage i had to use for any sleeping pill was ridiculously low.....something was way off with this HPA axis I think. seems to be fixing now. I believe it was this axis but it could also be some excitatory transmitter but vortioxetine at 5-10mg which im using is mostly a 5tht3a blocker and SRI.

    my sleep patern is:
    - fall aslep for 5 hours
    - lay awake for an eternity
    - possibly sleep again in 2-4 hours time if the Gods allow and there is no anxiety to block it.

    I also have this pattern for many years.
     
  5. drob31

    drob31 Senior Member

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    The gyno is from high prolactin and or estrogen. You can control this with aromatase inhibitors and D2 agonists like cabergoline for prolactinemia.
     
  6. drob31

    drob31 Senior Member

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    Taking tyrosine seemed to help me for a few months. Then I'm pretty sure some co-factor go diminshed like tyrosine hydroxylase, and I seem to feel different than before. There is defintely a neurotransmitter connection, something to do with dopamine and cortisol receptor resistance.
     
  7. drob31

    drob31 Senior Member

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    Do you think I should try the dex?
     

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