Hey all, This is my first post on this forum but I've been reading for a little while and it seems like a good place to post this kind of thing. I've been dealing with brain fog for the past 3.5 years to varying degrees of intensity. Before that I had quite a lot of anxiety and obsessive thinking patterns but now my main complaint is generally the intense brain fog, although the OCD thoughts do bug me sometimes still as well. I've been to many doctors and taken many tests. I've tried a variety of supplements and methods but generally supplements seem to make the symptoms worse. The fog mostly started around the time I replaced my amalgam fillings (3.5 years ago) out of concern for mercury poisoning, as a result I have always seen heavy metals as a potential cause for the fog, but other possibilties seem just as likely. Diet definitely plays a factor but it has been hard to identify exactly what causes a worsening of symptoms. I have noticed probiotics, both in foods and supplements, tend to cause an increase in symptoms. I'm not sure if this is due to leaky gut or some kind of herx reaction but I do take 1 Dr. Ohhira probiotic each day before bed as my only current supplement to try to stablize my microbiome. I have taken several recent tests that have shown interesting findings: Here is my Genetic Genie interpretation of my 23andMe results: COMT V158M rs4680 GG -/- COMT H62H rs4633 CC -/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CT +/- VDR Taq rs731236 AG +/- MAO-A R297R rs6323 TT +/+ ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 AG +/- MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 TT -/- MTR A2756G rs1805087 AA -/- MTRR A66G rs1801394 GG +/+ MTRR H595Y rs10380 __ no call MTRR K350A rs162036 AA -/- MTRR R415T rs2287780 __ no call MTRR A664A rs1802059 AG +/- BHMT-02 rs567754 TT +/+ BHMT-04 rs617219 __ no call BHMT-08 rs651852 TT +/+ AHCY-01 rs819147 TT -/- AHCY-02 rs819134 __ no call AHCY-19 rs819171 TT -/- CBS C699T rs234706 AA +/+ CBS A360A rs1801181 GG -/- CBS N212N rs2298758 __ no call SHMT1 C1420T rs1979277 __ no call Heterozygous: MTHFR C677T VDR Bsm VDR Taq MTRR A664A Homozygous: MAO-A R297R MTRR A66G BHMT-02 BHMT-08 CBS C699T A recent blood test showed the following: - Excessive folic acid (>24) - High Anti Thyroid Antibodies ab (61) - High T3, Reverse (21) - Mid/low B12 (427) - Always have very low cholesterol - Lyme negative - WBC on the low side (4.73) - Homocysteine serum on the high side (11.1) - Low Creatinine (.88) - High BASOS (2.3) - Low Vitamin D (20.8) Urine toxicity test: - Low Molybednum Cortisol saliva test: - 3-5pm result was much higher than normal (.67) Stool test: - elevated phospholipid excretion (decreased absorption) - Fecal fat total and Long Chain Fatty Acids also nearly out of reference range (elevated excretion) - blood in stool - No growth (lack of) Lactobacillus species bacteria I know that's a lot of information and probably not even the full picture. I've been seeing a naturopath who has been helpful in guiding me but have not seen any really positive results. The last thing she had me try was a quality multi-vitamin that includes the spectrum of B vitamins in the form I need (according to MTHFR). That has noticeably increased the fog so I went off it. Sometimes I'm not sure whether it's worth sticking it out and trying to make it through the fog to see if it ultimately helps or if I should stop the supplement. Any advice would be welcome and much appreciated!