ahmo
Senior Member
- Messages
- 4,805
- Location
- Northcoast NSW, Australia
@twincity Natasha CAmpbell-McBride in GAPS diet promotes high animal fat diet to heal and seal gut and brain. My sense is that this has been very helpful for me.
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To become a member, simply click the Register button at the top right.
It should help. I think it comes before the methylation supps.I'll pursue the initial B2 dosing as well, just in case that helps too.
I'd suggest that you discuss your symptoms with your doctor.
What do you mean by that?it seems that the COMT SNP is a pretty cast-iron diagnosis
What do you mean by that?
I think it means that if one is +/+COMT troubles with neurotansmitter breakdown will be present sooner or later.What do you mean by that?
I'm looking forward to that.I think it means that if one is +/+COMT troubles with neurotansmitter breakdown will be present sooner or later.
Be sure to always have magnesium in the cupboard.I'm looking forward to that.
It's definitely not diagnostic ... it's an extremely common variation, and generally doesn't result in any problems. Some mildly increased risks are associated with it, but so are some mildly decreased risks.I mean that the COMT V158M +/+ polymorphism shows that your COMT activity is significantly lower than for people without the polymorphism.
It's a definite indication of underperforming COMT activity. It's not a flag saying that you're statistically more likely to suffer from a certain condition.
It's definitely not diagnostic
Sure, it impacts gene function. But there's no indication that the high prevalence of variable function in that gene is particularly problematic. Just some mild associations with various personality and psychological traits in psych research, which tends to lack scientific rigor.I'm not talking about symptoms or problems. I'm talking about the impact of the altered gene. It lowers the activity of the COMT enzyme.
Sure, it impacts gene function. But there's no indication that the high prevalence of variable function in that gene is particularly problematic.
There are indeed modest associations. These can be aggravated by methylsupplements, so this is of particular importance for individuals who are adressing methylation which makes treatment much more difficult, especially if there is a combination of COMT mutations or if that person has anxiety/mood swings/bipolar.Just some mild associations
Is there research supporting this? Or is it another "Yasko says"?These can be aggravated by methylsupplements . . .
It's a @TheChosenOne says, and also a bunch of other people who have COMT mutations. That's why I said 'can' and not 'will'.Is there research supporting this? Or is it another "Yasko says"?