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23 and me results

Discussion in 'Genetic Testing and SNPs' started by maryb, Jul 19, 2013.

  1. maryb

    maryb iherb code TAK122

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    Hi folks be grateful for any opinions on my results.

    Valentijn - thank you for your help - my computer guru:)

    [​IMG]a
    Valentijn likes this.
  2. Sea

    Sea Senior Member

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    I can't see your results? Just a little rectangle with a ? inside it
  3. Valentijn

    Valentijn Activity Level: 3

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    Hrm, I can see them ... can you right-click and "view image" Sea ?
  4. Sea

    Sea Senior Member

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    Nope, I'm on an ipad at the moment. Maybe it will be different when I get back to the computer
  5. Valentijn

    Valentijn Activity Level: 3

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    maryb
    You have the slow versions of COMT and MAOA. This means some neurotransmitters (serotonin, dopamine, norepinephrine, and epinephrine) stick around longer. So taking supplements which are precursors to those might be unpleasant. Methyl groups also shouldn't be needed, and might be unpleasant. So supplementing high doses of methylB12 could be a bad idea - hydroxyB12 might work better if you try B12.

    VDR Taq means you might be a bit slow in producing in dopamine, norepinephrine, and epinephrine. That's probably a good thing, since you're also slow in getting rid of them

    MTHFR A1298C means you might have a little methylfolate-related trouble, and supplementing methylfolate might be helpful. But a small or normal dose might be a better place to start if you do try it - not high doses, due to your slow COMT and MAOA.

    MTRR might result in slightly elevated homocysteine, due to possibly slower conversion of homocysteine into methionine. But the studies I've seen only show this happening to people who are "GG", not "AG". If your homocysteine is elevated, you might need methylB12, but due to your slow COMT and MAOA, it might be a good idea to get homocysteine tested to see if there's a problem before trying methylB12.

    MTRR A664A doesn't have an impact on the functioning of the gene, so no need to worry about that one. Same for CBS A360A.

    SHMT1 is also only known to have an impact when homozygous (AA), but at most it might mean that a little methylfolate and folinic could be helpful.

    SUMMARY:
    You should probably stay away from supplementing high doses of methylB12 or methylfolate, though a small or normal dose of methylfolate might be helpful, and hydroxyB12 should be safe. A normal dose of folinic acid also might be helpful. It might be worthwhile to get your homocysteine tested (if it hasn't already been) to make sure nothing is going on with that.
    Nielk likes this.
  6. maryb

    maryb iherb code TAK122

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    Valentijn
    thanks so much - you're absolutely right - I can't tolerate methylb12 injections but am fine with hydroxyb12.
    will homosysteine come up in a aminoacids test?
    maybe the new Yasko multi may be low enough for me - I just struggle to find one that I can tolerate. and it makes sense why now.
    Valentijn likes this.
  7. Valentijn

    Valentijn Activity Level: 3

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    It depends on the company, but I think most would have it. There should be a list somewhere of which amino acids the test reports on. It's also a pretty common part of blood work that even a normal doctor would order.
  8. maryb

    maryb iherb code TAK122

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    thanks - do you or anyone know how the Methylation Panel by DDI differs from the 23andme one? I was asked to do either one.
  9. Valentijn

    Valentijn Activity Level: 3

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    It looks like the DDI (Doctor's Data Inc) measures actual levels of things in the blood relating to the central methylation process. It would show actual problems, and combined with the genetic data might give a better idea of where problems are (or aren't) originating.

    The downside to that sort of testing is that it's pretty expensive usually. Something similar from a local lab is 300 euros ($400), and DDI doesn't list their prices, which usually isn't a good sign :p
  10. maryb

    maryb iherb code TAK122

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    Thanks V - yes it is much more expensive - $495 for the Meth Panel:eek:compared to $99 for the 23andme.
  11. Valentijn

    Valentijn Activity Level: 3

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    So trial-and-error of methylation treatments with genes to guide you a bit might be more feasible :p
  12. maryb

    maryb iherb code TAK122

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    Valentijn
    I think so, but there again in the grand scheme of things given what I've spent on doc, treatments etc and of course my great age:( should I just try to gain every bit of info I can to help the doctors work out what is wrong so I can maybe enjoy a bit of life?
  13. Valentijn

    Valentijn Activity Level: 3

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    Well, you could just try treating the things that would come up with an actual blood test, and see if the treatment works. In this case, it might be a lot cheaper than testing then supplementing :p But if you want test it and can afford to, then might as well.
  14. maryb

    maryb iherb code TAK122

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    Valentijn
    just noticed you said 'trial and error' oh no I can't bear any more of that. the meth panel it is then:)
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  15. caledonia

    caledonia

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    DDI Methylation Test = $200 but I don't know if it's that useful http://www.integrativepsychiatry.net/methylation-test.html

    I think you're confusing this with Yasko's SNP test with is also called a "Methylation Panel" which is $495.

    As far as functional testing (what's going on in your body vs. a SNP test), Nutreval is the best.
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  16. maryb

    maryb iherb code TAK122

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    I do like the look of that Nutreval one but this specialist has asked for DDI or 23and me. Its not the one on that link caledonia
  17. caledonia

    caledonia

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    Do you have a link to the actual DDI test, so I know what it measures?
  18. maryb

    maryb iherb code TAK122

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  19. caledonia

    caledonia

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    That's Yasko's SNP test. Your doc is asking for methylation pathway SNP tests, either 23andme or Yasko.

    Ok, so back to your original question, what is the difference between these two SNP tests. Yasko's is the original one. It is a blood test. It has 31 methylation pathway SNPs. A blood test is supposed to be 100% accurate. You should get Yasko's interpretation and supplement recommendations and her book and some other info along with it. Wait times, I think about 8 weeks.

    23andme is a saliva test. It tests around a million SNPs. Saliva is supposed to be 98 or 99% accurate. The chances of one of your methylation SNPs being wrong is pretty slim, but I have heard of it happening to one or two people. There are 5 SNPs missing compared to Yasko. You will need to extract the correct SNPs and interpret them outside of 23andme. You can do it yourself, but I assume your doc already knows how to do that, and will do it for you. Wait times are running about 6 weeks.

    You can also pull out the same detox pathway SNPs used in the Genova Detoxigenomics test.

    Of course, there are still almost million other SNPs to look at. As time goes on, other SNPs might be deemed important and you would already have that info at your fingertips. So overall, 23andme is an incredible bang for the buck.
  20. maryb

    maryb iherb code TAK122

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    caledonia
    so you wouldn't bother doing the Yasko test if I already have the 23andme results?
    You know its probably difficult for you more knowledgeable ones to understand how hard its is for us on the other side - but I have to admit I don't know what a SNP is?
    and yes I'm hoping for some guidance through it all but it won't be for a while yet.

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