I don't propose I have *the* answer or anything, but I am wondering if there might be 2 distinct branches to the ME/CFS "family tree" of diseases. I say diseases plural because there are so many distinct and opposite reactions to treatment protocols etc that there have to be a few different underlying processes causing overlapping symptoms. (I don't think this is too controversial a view; I am saying ME/CFS is not A real thing but rather a FEW or perhaps SEVERAL real things) That said, here are my questions. I don't want to bias anybody so I will wait a little while to propose my hypothesis. Did you have IBS before or early on in your symptoms? Do you have sinus problems? Do you have autoimmune disease also? (Perhaps I could say "another" but that's a bit loaded) Do you have MCS? If you have tried it, did you get lasting benefit from LDN? I expect 2 main distinct patterns of yes/no answers but I won't say what they are just yet thanks!