Sean Lynch, a psychiatrist, has now responded, approx. 24 hours after my comment went up. Authors get automatic alerts for responses - I wonder whether there might be a connection? His defence of the changes to the PACE Trial protocol largely seem to depend people trusting him as some sort of expert, perhaps an unbiased expert. There is little substance in them. It's like an appeal to authority. Sean Lynch was one of the co-authors of the Royal Colleges of Report on CFS (1996) (Word file of this is available here: http://bit.ly/HFQeOM ). As well as recommending CBT and GET, and little else, it gave very few suggestions for biological research. He calls for more trials like the PACE Trial. [..] so that'd be CBT and GET trials and the like.