I started taking extremely tiny doses of methylfolate and mB12 about 14 months ago. (Here is how I started: http://forums.phoenixrising.me/show...ERY-low-very-slow-results&p=173804#post173804 ) I have maintained my improvement in energy levels. My remaining problems are fibromyalgia-like pain (this makes it difficult to increase exercise since its so easy to injure myself), anxiety, and chemical sensitivity. Im writing to mention something that happened in the past few months with the supplements. I happened to notice that my mB12 capsules had passed their expiration date, by 6 months or so (I got them several years ago but was too afraid to start for a few years). So, I ordered new bottles of both methylfolate and mB12. Keep in mind that at the doses I take, one bottle of each would probably last me the rest of my life, since I take tiny specks of a tablet/capsule, then dilute them in water. I started the new bottles and was surprised to experience some of the same start-up reactions I had from a year ago sore teeth, headaches, tired (but not necessarily in a CFS-kind-of-way). My conclusion is that even at my tiny, diluted doses, these supplements are doing something. To be more concrete, Ill explain how the supplements changed my work experience. Ive had the same (demanding) part-time job for 7 years. Before the supplements, it was a struggle. On my days off, I would have to lie flat several times a day to try to manage the fatigue/weakness. Before going to work, Id lie flat for at least an hour. Since using the supplements, I only lie down if I am sick (like a regular person). I cant say I have the energy of a normal person, probably not even close, but the improvement is significant. Id love to work more, but my chemical sensitivities are the main problem holding me back Id love to solve that puzzle! So, my take-home message is: I think the supplements really can/do work..and check those expiration dates!!