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0.05 or 0.005? P-value Wars Continue

Discussion in 'Other Health News and Research' started by AndyPR, Aug 2, 2017.

  1. AndyPR

    AndyPR RIP PR :'(

    Got to admit I didn't read this, other than the first couple of paragraphs, but thought it might interest others here.

    https://sciencebasedmedicine.org/0-05-or-0-005-p-value-wars-continue/
     
    Demepivo, slysaint, Simon and 4 others like this.
  2. Sean

    Sean Senior Member

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    This would be an important step forward.
     
    AndyPR likes this.
  3. adreno

    adreno PR activist

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    With the amount of bad research out there lately, I would suggest going with 0.005. This still won't prevent p-hacking, of course.
     
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  4. Forbin

    Forbin Senior Member

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    Well, as an exercise, in the Stanford study the following met the p < 0.005 threshold:

    FDR-adjusted p-values:

    ME.CFS patients vs. Controls: Resistin, TGF-β [Both p-values were actually 0.0052, or 1 in 192 vs. 1 in 200]

    Unadjusted p-values:

    ME/CFS patients vs. Controls: Resistin, TGF-β

    Mild vs. Controls: Leptin, Resistin
    Moderate vs. Controls: ICAM1
    Severe vs. Controls: IL-7, IL-13, NGF, Resistin

    Linear Trend Analysis: CCL11, CXCL10, G-CSF, GM-CSF, IFN-γ, IL-4, IL-5, IL-7, IL-12p70, IL-13, IL-17F, Leptin, LIF, NGF
    Non-Linear Trend Analysis: ICAM1, Resistin
     
    Last edited: Aug 3, 2017
  5. adreno

    adreno PR activist

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    I suppose you mean p<0.005 ;)
     
  6. Forbin

    Forbin Senior Member

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    :)
     
    Last edited: Aug 5, 2017

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