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‘Off switch for pain’: scientists find new way of shutting down pain

Discussion in 'Other Health News and Research' started by Bob, Nov 27, 2014.

  1. Bob

    Bob

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    England (south coast)
    ‘Off switch for pain’: scientists find new way of shutting down pain
    27 November 2014
    The Independent
    http://www.independent.co.uk/news/s...nd-new-way-of-shutting-down-pain-9888339.html

    And here's a more scientific article...

    'Off switch' for pain discovered: Activating the adenosine A3 receptor subtype is key to powerful pain relief
    November 26, 2014
    Science Daily
    http://www.sciencedaily.com/releases/2014/11/141126132639.htm
     
  2. Bob

    Bob

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    This is the research paper...

    Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states
    Joshua W. Little et al.
    First published online: 20 November 2014
    Brain
    DOI: http://dx.doi.org/10.1093/brain/awu330
     
  3. lansbergen

    lansbergen Senior Member

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    Critically, engaging the A3AR mechanism did not alter nociceptive thresholds in non-neuropathy animals and therefore produced selective alleviation of persistent neuropathic pain states.

    So this could explain the difference between ME pain and injury pain?
     
    Bob likes this.
  4. Navid

    Navid Senior Member

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    Are there clinical trials in the US using these?

    thanks, Navid
     
  5. Sean

    Sean Senior Member

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    Off switch for pain.

    That would be nice. :cool:
     
    Bob likes this.
  6. adreno

    adreno PR activist

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    I don't think that can be concluded. It means that normal animals did not lose/change their ability to feel pain - which is critical. You don't want to lose your sense of pain, or you'll end up cutting your finger off, or worse.
     
    Valentijn likes this.
  7. lansbergen

    lansbergen Senior Member

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    But it helped for neuropatic pain?
     
  8. adreno

    adreno PR activist

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    Yes, it helped with chronic, neuropathic pain.
     

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