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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. caledonia

    Roadblocks to Successful Methylation Treatment

    I did the CBS protocol and was able to get my sulfur reduced. But it didn't help me feel any better, other than I could tolerate sulfur foods and supplements better. You would need urine sulfate strips to monitor things. If you do have a CBS/sulfur issue, consider that you could have an...
  2. caledonia

    Roadblocks to Successful Methylation Treatment

    When you take B12 and folate (folic acid), that will crank up the methylation cycle. It's like a runaway train - it will take a long time to stop even if you discontinue all the B12 and folate. It doesn't really sound like you're having overmethylation symptoms except for needing a lot of...
  3. caledonia

    Roadblocks to Successful Methylation Treatment

    I will get back to you soon. I need to refresh my knowledge on the subject and look back in my symptom journal. In the meantime, I remember was taking 3000mg of potassium per day for several years. You get that much in food (assuming you can digest it from your food which you may not be able to...
  4. caledonia

    Roadblocks to Successful Methylation Treatment

    It will get you back to normal. But you will likely have to dose the niacin several times a day until the symptoms settle down. Could take days or weeks. Basically, the niacin is taken every four hours or whenever symptoms return. You keep taking it until you're feeling better. I noticed I...
  5. caledonia

    Roadblocks to Successful Methylation Treatment

    I have some normal niacin (nicotinic acid) in my cupboard which I remember using, so it's probably fine. If I remember correctly, the amount to try is 50-100mg. If you get a niacin flush, don't be alarmed, just try a smaller amount the next time. The niacin flush looks and feels somewhat like a...
  6. caledonia

    Genetic variants (SNPs) Interpretation Guide

    Hi Muzaffar, I've heard of it, but haven't personally tried it. It seems to be mostly used for FM type pain. I searched for it on the Cutler Facebook forum, and there are a number of posts. It looks like it helps some people, but others have trouble with tolerating it. There is no issue with...
  7. caledonia

    Genetic variants (SNPs) Interpretation Guide

    There is a specific hair test to get, and a specific way to interpret it. My suggestion would be to go ahead and contact Rebecca, and she can help you with your various questions. Or you can ask them on one of the Cutler forums or groups. Rebecca has a link to the hair test on her website which...
  8. caledonia

    Genetic variants (SNPs) Interpretation Guide

    I see you have autism and ADHD. What I suggest is to skip looking at all the things you mentioned. I have years of personal experience doing extensive research on those, trying some of them, and a bunch of other things, and it's a giant rabbit hole. Instead I suggest checking out the Andy...
  9. caledonia

    Start Low and Go Slow - How to Be Safe On A Methylation Protocol

    Yes, there can be a honeymoon period where you feel ok, then things can take a turn for the worse.
  10. caledonia

    Start Low and Go Slow - How to Be Safe On A Methylation Protocol

    It's one of those things, you will feel so bad, that you will know. My symptoms were a horrible revved up anxious/toxic type feeling. Other people have reported needing to go to the emergency room or even feeling suicidal.
  11. caledonia

    Managing Potassium Deficiency - Share your experience

    When my potassium goes low I also get loud ringing in the ears. It's just temporary and goes back to normal when I get my potassium levels back to normal. However, I do normally have a bit of tinnitus. I can hear it at night when it's quiet. Tinnitus is a symptom of mercury.
  12. caledonia

    Start Low and Go Slow - How to Be Safe On A Methylation Protocol

    I googled, and it does look like potassium could lower blood pressure, while sodium (salt) would raise it.
  13. caledonia

    Those who have stopped methyl supps due to bad reaction, how long did it take to get back to normal?

    Hi, Based on my own experience, my suggestion would be to discontinue B vitamin supplementation for now. Then take 50-100mg of the nicotinic acid form of niacin until your over methylation symptoms clear up. You may need to dose several times a day for several days. Last time it happened to me...
  14. caledonia

    Managing Potassium Deficiency - Share your experience

    I'm doing the Cutler protocol, and it's been the best thing I've ever tried. They have people take a hair test to see if they have mercury or other toxic metals making them sick. The right hair test is the Doctors Data Toxic and Essential Elements. There is a trick to interpreting the hair...
  15. caledonia

    Managing Potassium Deficiency - Share your experience

    Hi, Boy, that is an old post from me! I'm currently taking Now brand potassium gluconate, and Seeking Health brand magnesium malate. I still can't take much in the way of B vitamins - I get mine from a bit of beef liver once a week.
  16. caledonia

    multiple chemical sensitivity medically assisted suicide

    Hi, if your phase 1 is already slow, you're halfway there. Just concentrate on speeding up phase 2. I don't think it would hurt to take something like vit. C, which does both. I also can recommend doing the Cutler protocol and trying out his suggestions for MCS. My MCS is greatly improved...
  17. caledonia

    Ron Davis Hair Analysis (HTMA)

    Hair samples are washed in the lab to eliminate environmental contamination. https://www.doctorsdata.com/FAQs#:~:text=A%3A%20All%20hair%20samples%20are,been%20excreted%20into%20the%20hair.
  18. caledonia

    Trying Colloidal Silver. Instructions? Probiotics?

    Have you seen a doc for the bleeding? If so, what was the result? I don't understand how the gut can affect this?
  19. caledonia

    Trying Colloidal Silver. Instructions? Probiotics?

    Yes. Some of them turn blue. Google "argyria".
  20. caledonia

    Trying Colloidal Silver. Instructions? Probiotics?

    It's a toxic metal. It can't be chelated back out. If you have gut issues, there are plenty of other non toxic remedies.
  21. caledonia

    Alpha lipoic acid may help restore circadian rhythms, help with sleep

    Caution with ALA - this video explains it better than I can:
  22. caledonia

    PFS Sufferer -- help with 23andMe?

    @Outlaw #2 - google "does dietary B6 cause neuropathy?" and you'll see lots of articles from authoritative sources that supplemental B6 can cause neuropathy, but dietary B6 doesn't. Supplemental B6 is a mega dose compared to what you can get from your diet. So I think the issue is not the...
  23. caledonia

    PFS Sufferer -- help with 23andMe?

    Hi @Outlaw, I'm glad you've found my guides helpful. I wrote them so long ago, that I don't remember the details any more. This page suggests that high B6 is ok as long as it's from the diet, and not from supplements. https://healthmatters.io/understand-blood-test-results/vitamin-b6 You could...
  24. caledonia

    multiple chemical sensitivity medically assisted suicide

    Very sad, because MCS can be treated with either neutralization drops from an environmental medicine specialist or things that slow phase 1 detox and speed up phase 2 detox (vit. C and/or niacinamide). Checking for toxic metals like mercury and arsenic and chelating those out should get to the...
  25. caledonia

    B12 causing restlessness, anhedonia and sexual dysfunction

    There are several hypotheses that are plausible. What I'm suggesting is an orderly set of trials to help rule things in or out, so you can hopefully figure out what the issue is. If you try niacin and it helps, that would confirm overmethylation. If not, then you can try electrolytes or other...
  26. caledonia

    B12 causing restlessness, anhedonia and sexual dysfunction

    Ok, so there is the smoking gun. B9 = folate (aka folic acid). You are taking 1000mcg of cyanocobalamin (B12) and 400mcg of B9 (folate - form unknown) I would guess that there is a high chance that you have become overmethylated. Your restlessness and anxiety symptoms also match with being...
  27. caledonia

    B12 causing restlessness, anhedonia and sexual dysfunction

    Just read any of the number of posts on this website where people are posting in panic because they got overmethylated. Usually it takes B12 + folate supplements. Those two work together to create methyl groups. The doses are usually way higher than what you get from food, so it creates excess...
  28. caledonia

    B12 causing restlessness, anhedonia and sexual dysfunction

    Methylation is one of several cycles in your body that operate things all over the body. It happens thousands of times a second in all your cells. Methylation uses B12 and folate in its cycle. So if you're taking B12, you're increasing the rate of methylation, assuming there is enough folate...
  29. caledonia

    B12 causing restlessness, anhedonia and sexual dysfunction

    Dr. Ben Lynch has done a lot of work on methylation, including B12. This Facebook post has a lot of good info on troubleshooting B12 issues. He's saying #1 to take electrolytes...
  30. caledonia

    negative symptoms after taking vitamin d

    Yes, I've had issues with both calcium and vit. D. The reason is that magnesium is a co-factor for both. You're probably low in magnesium. You can be low despite supplementation. You may need to increase supplementation a lot more and also dose the magnesium four or more times a day and night...