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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. C

    Advice Needed - Mitochondrial Dysfunction/Methylation Protocol/Worsening of Symptoms?

    Thanks Rachel!
  2. C

    Advice Needed - Mitochondrial Dysfunction/Methylation Protocol/Worsening of Symptoms?

    Thanks for the advice, everyone. I really appreciate it. I added the SAM-e into the mix a few weeks ago, and the Alpha-lipoic acid I'm taking (100mg) doesn't seem like enough (dosage-wise) to be the culprit. And then the methylmate before that. And before that the methylguard. I keep a journal...
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    Advice Needed - Mitochondrial Dysfunction/Methylation Protocol/Worsening of Symptoms?

    Hi All, Apologies in advance for the lengthy post. I’m new to this forum and I’d love input on the following if you have the time. I'm a 34-year-old female. I started a methylation protocol about 6-7 weeks ago, and as many of you have noted in your experience, my main symptom (intense leg...