• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. P

    Community symposium on molecular basis of ME/CFS at Stanford Discussion Thread

    Was tryptophan elevated after giving the patients a tryptophan supplement or just a standard measurement?
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    How I put ME/CFS into remission....& even better

    i feel sorry for your daughter..
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    Increased Body Temperature Variation?

    Basal metabolic rate is important for maintaining body temperature. Some deficiencies that reduce it can cause problems with maintaining body temperature.
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    Need advice quite urgently

    Has she been tested for zinc deficiency? Zinc deficiency can cause diarrhea. High histamine foods might also cause issues for some people.
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    High prolactin

    Prolactin can increase vitamin D activation
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    Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)

    https://forums.phoenixrising.me/index.php?attachments/blood-gas-results-jpg.21391/ These test results are weird though, or maybe I'm getting it wrong? :wide-eyed: https://www.researchgate.net/publication/19462235_Muscle_power_and_metabolism_in_maximal_intermittent_exercise I think the ranges...
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    Methyl folate severe crash

    Have you ever tried supplements for your anxiety? I have some good experience with hydroxoB12, 5-HTP and choline bitartrate. I heard from someone who was on SSRI's that they then needed choline and it was helpful for some symptoms like sensory overload. I had the feeling choline can lower...
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    Acid-Base disturbances, low bicarbonate?

    Calcium as an Enzyme Cofactor Enzyme location: Cytosol, Glycosome or extracellular Glucose metabolism · Activating glycogen phosphorylase, which converts glycogen to glucose https://en.wikipedia.org/wiki/Glucose_6-phosphate · Inhibiting glycogen synthase that catalyzes the conversion from...
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    Cortene Peptide for MECFS? "Curative"?!

    Although I think it's good that drugs are being tested for ME/CFS, I don't see this drug affecting some of the core issues of ME/CFS. So I would try not to get my hopes up too much. I think the strong stress reaction that can be seen in ME/CFS is rather result of low energy levels and low...
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    Acid-Base disturbances, low bicarbonate?

    Apart from high NADH/H+, ATP and acetyl-CoA, what inhibits the pyruvate dehydrogenase is a lack of cofactors (vitamin B1,B2,B3,B5, alpha lipoic acid, Mg, Ca). https://www.sciencedirect.com/science/article/pii/S000527280900036X Calcium signaling has been implicated as a mechanism that enables...
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    Acid-Base disturbances, low bicarbonate?

    What causes acidosis? There are different opinions on what the cause of acidosis during exercise is. https://en.wikipedia.org/wiki/Lactic_acid#Exercise_and_lactate pH describes the invert concentration of protons/H+ in a solution. In a high pH/base solution, concentrations of protons are low...
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    Blood parameters indicative of oxidative stress are associated with symptom expression in CFS

    https://en.wikipedia.org/wiki/Methemoglobin https://en.wikipedia.org/wiki/Cytochrome_b5_reductase Vitamin B2 is pretty helpful for me, I've been having some mixed reactions to B3 lately. NADH/H+ of course depends on B3/NAD+, but also on energy processes, citric acid cycle,.. in general.
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    Blood draw - what are the most important tests at the beginning?

    agree with @pattismith to test B12, folates, iron panel also vitamin D Doing a mineral status, preferably intracellular status might also be helpful (calcium, magnesium, zinc, sodium,..) Coenzyme Q10 levels might also be interesting. Magnesium and ubiquinol/ coenzyme Q10 help some people. Don't...
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    Now very severe HELP

    I don't tolerate folic acid and vitamin B6/pyridoxine well. Maybe I'd try getting an injection with hydroxoB12 only. Hydroxocobalaminhydrochloride is the same as hydroxoB12. I've had problems with having too much B12, that seems to differ individually. Maybe you'll have to see how he reacts...
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    Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)

    In general on the oxygen saturation, as I understand it, the oxygen dissociation curve describes how easily oxygen binds to hemoglobin. When curve is shifted more to the right, hemoglobin binds less to oxygen/ dissociates more from oxygen. This leads to more oxygen being released to tissues, but...
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    #OMFScienceWednesdays-What do T cells and B cells do?

    Thankyou for posting! I was just trying to understand this, but didn't really have energy to look up much :thumbsup::lol: Does anybody know if there are any findings or theories on how T cells behave in ME/CFS?
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    Livestream on Tuesday with Dr. Ron Davis on panel after Unrest screening

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    Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)

    I've been looking into low oxygen saturation lately: http://derangedphysiology.com/main/core-topics-intensive-care/arterial-blood-gas-interpretation/Chapter 4.0.5/factors-which-influence-affinity-haemoglobin-oxygen 2,3-DPG= 2,3-Biphosphoglycerate The first diagram in this link is good too...
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    Livestream on Tuesday with Dr. Ron Davis on panel after Unrest screening

    The livestream can be viewed here (4AM UK time?): https://livestream.com/berkeleyhealth/unrest The event is scheduled from 4:30 PM – 8:00 PM Pacific Time, with the panel discussion after the Unrest screening. More details on the event here.
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    Acid-Base disturbances, low bicarbonate?

    https://journals.lww.com/aidsonline/Fulltext/2000/03100/l_Carnitine_as_a_treatment_of_life_threatening.29.aspx LA= blood lactate https://www.researchgate.net/publication/14328808_Influence_of_thyroid_hormones_on_exercise_tolerance_and_lactate_threshold_in_rats Q10 deficiency can inhibit the...
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    Acid-Base disturbances, low bicarbonate?

    My current understanding (vague, possibly wrong): Acid and Base- balances seem to be more complex in the body than in standard chemistry and watery solution, as production of acids, bases and protons seems connected to how much some pathways function. Shifted metabolisms (this sounds so...
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    Desperate for HELP or support for extreme burning generalized skin pain

    Hi @Starsister I am so very sorry about what you are going through. I am a bit low on energy so I couldn't read the whole thread. About the burning skin pain: A thread on this is here- Burning sensation on skin Histamine and mast cell activation syndrome might be an issue. One person writes...
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    vitamin b recommendations

    Hey @Pink I had troubles with b-complexes, too. What comes to mind first when I'm looking at the b-complex you are taking: Folic acid: Folic acid is a synthetic form of folate, it is not found naturally in foods. To be activated it needs to be metabolized by the enzyme DHFR, which requires...
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    Comment by 'PinkPanda' in 'MY WORLD...AND CHRISTINA'S WORLD'

    I love the painting and your response paintings to it!
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    Low T3 syndrome caused by energy restriction

    @Sundancer B2 helped me with histamine symptoms, fatigue after meals and general mood. Also had an overall good effect on my body, like relaxing muscles. I always had problems with the muscles in the back of my neck and B2 really helped relax them. I have the experience that it can induce...
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    Stanford News: Davis- Tweak to assay could bolster disease detection

    New research by Ron Davis and the Stanford Genome Center on an improved method to detect certain biomarkers Full article here https://med.stanford.edu/news/all-news/2018/02/tweak-to-assay-could-bolster-disease-detection.html
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    Low T3 syndrome caused by energy restriction

    This series on the thyroid you are posting is really interesting!:thumbsup::lol: I get very few symptoms of high lactate, but I have some signs of thyroid dysfunction in my tests and inactive hashimoto. I really think thyroid dysfunction is a main issue that reduces my energy production. Or as...
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    Cortene Peptide for MECFS? "Curative"?!

    I don't know about this. They seem to be putting some high expectations out there.. Does anyone understand how exactly this drug will affect stress receptors in the limbic system? I think the limbic system might currently be getting too little attention in medicine. Still, although there is...
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    Can Rituximab work in patients with no known autoimmunity?

    We had a discussion on the issue in this thread https://forums.phoenixrising.me/index.php?threads/ivig-treatment.56545/page-2#post-940846 this and the following posts are about that there is a group of people who show signs of autoimmunity and fatigue, but do not fit the criteria of an...
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    Acid-Base disturbances, low bicarbonate?

    https://labtestsonline.org/conditions/acidosis-and-alkalosis