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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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    BH4 and the Genetics of ME/CFS

    Hi Mimi, I have gs224 (gch1) and supposedly a variant for PKU according to Promethease. I am also homozygous for: SOD 2 , CBS C699T, COMT v, COMT h, NOS 3, MTHFD1, SLC19A1 Hetero for many Snps but will only list a few: SOD 3, VDR BSM, VDR TAQ, NOS 2, MTHFR C677T, MTHFS, MTRR, AGT, AHCY, BHMT...