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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Search results

  1. O

    NIMODIPINE use in M.E. / CFS : A comprehensive guide. S. Parker (MBA, BSc) January 2014

    This is a great drug. I take this drug if necessary to compensate for the "excessive" load (adrenaline stress, as a channel blocker). Safe.
  2. O

    HHV-6 researcher Dr Bhupesh Prusty also finds "something in the serum" of ME/CFS patients

    Brain tissue exhibited a significant inverse correlation for immunostaining between cytochrome c oxidase subunit 1 (CO1), a MtDNA encoded enzyme subunit, and HSV-1; with lower abundance for mitochondrial protein in regions where HSV-1 was abundant. https://www.ncbi.nlm.nih.gov/pubmed/27457581
  3. O

    Enteroviruses - revisited

    The quality of recombinant interferon is very important. In Russia, the quality is very poor. It causes inflammation due to impurities from other components in its production.
  4. O

    PENE, nitric oxide and nitrosative stress

    Yes, I'm a little not attentive;) Yes, I thought you would give an answer why, for example, with multiple sclerosis, homocysteine is lowered. I have lower than normal and homocysteine and uric acid.
  5. O

    PENE, nitric oxide and nitrosative stress

    This question interests me. I have below normal homocysteine And arginine infusions make my condition worse thanks
  6. O

    PENE, nitric oxide and nitrosative stress

    ???
  7. O

    Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ [...]

    can you explain this? I have been taking niacin for a long time. He helps me a little.
  8. O

    Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ [...]

    What is the composition of the cocktail?
  9. O

    Why did antivirals (valcyte, etc) for SEIDs fail?

    The main thing is not the name of the disease. An accurate understanding of its causes and the possibility of stopping the disease. myalgic encephalitis is a more cumulative name for the condition
  10. O

    Why did antivirals (valcyte, etc) for SEIDs fail?

    Waltrex did not help me. Famvir brought harm. Valcyte was effective. But I took it only 1.5 months.
  11. O

    Taking hydrocortisone before activity to prevent PEM crashes---I think that's on target!!

    That is why sleep does not provide recovery.
  12. O

    Looking for Benzodiazepine Damaged pwMEs (Klonopin, etc.)

    You are talking about the problem of benzodiazepines. But with what to replace them, when you need to decide what they decide .... Kava kava ... this is not serious ... How to remove the excitement, as a result of the disease ???
  13. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    I have access to standard analyzes https://www.synlab.ua/fileadmin/standortseiten/synlab_ua/lvz_v1.21.english_df.pdf
  14. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    What tests can be done to determine the functioning of mitochondria? Lactate
  15. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    Vitamin D enhances humoral immunity. Or, simply, increasing antibody production.
  16. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    How useful can antibodies to mitochondria be? (ama m - ama 9) https://www.labormedizin.at/laborbefunde/lbef2/lbef_ama.htm @Hip
  17. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    It seems to me that not low cortisol is a function of something. But this is not an independent failure. At the beginning of the keto diet, I felt a significant increase in energy. In the middle of the second month, a significant failure, first as a cold, then as a complete lack of strength ...
  18. O

    HBOT for ME/CFS/CFIDS

    https://forums.phoenixrising.me/threads/mitochondrial-and-energy-metabolism-dysfunction-in-me-cfs-myhill-booth-and-mclaren-howard-papers.47488/post-2229864
  19. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    I want to retell my experience and understanding. Yes, there is a strange global spasm of skeletal muscle, intestinal muscles, blood vessels .... The pressure chamber, pentoxifylline, arginine preparations do not work. Medicines working with calcium channels - nimodipine works great with...
  20. O

    Role of Capillary Size in ME

    https://www.ahajournals.org/doi/10.1161/JAHA.119.013602 Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies Background The etiology of postural orthostatic tachycardia syndrome (POTS) is yet to be established. The disorder is often...
  21. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    How much a major problem in the disease can be the pathology of mitochondria? Indirect or direct preparations: carnitine, ubiquinone, magnesium; keto diet; thyroid hormones ... Indirect: immunomodulators removing autoimmunity; antiviral drugs ... Everything is aimed at restoring the functioning...
  22. O

    Buying antibiotics for Lyme online

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316231/ Lyme disease is the most common vector borne-disease in the United States (US). While the majority of the Lyme disease patients can be cured with 2–4 weeks antibiotic treatment, about 10–20% of patients continue to suffer from persisting...
  23. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    Neurons are excitable cells that require large amounts of energy to support their survival and functions and are therefore prone to excitotoxicity, which involves energy depletion. By examining bioenergetic changes induced by glutamate, we found that the cellular nicotinamide adenine...
  24. O

    Mitochondrial and Energy Metabolism Dysfunction in ME/CFS — Myhill, Booth and McLaren-Howard Papers

    Thanks for this thread, @Hip , @paolo , @Norman E. Booth Very relevant. A ketogenic diet helped me. But after 1.5 months of being on a diet, there was a sharp breakdown and even greater fatigue, a fog in the head, "in general" no strength. The condition is similar to a pre-glycemic coma...
  25. O

    bad reaction to Famvir(famciclovir)

    More scientifically? Mechanisms ???
  26. O

    Transgenerational hypocortisolism and behavioral disruption are induced by the fluoxetine

    https://neurosciencenews.com/pregnancy-asd-antidepressants-12087/ A new study in mice reveals a possible link between the use of SSRI antidepressants during pregnancy and an increased risk of autism-like symptoms in offspring. Offspring exposed to fluoxetine (Prozac) in utero were more likely...
  27. O

    The limbs numb quickly with an uncomfortable position

    Hello Help to understand the symptom. With the growth of bad symptoms, a symptom that is incomprehensible to me appears. The limbs numb quickly with an uncomfortable position. Or when to put a foot on a leg, or to lay down incorrectly. Or curl up in a chair, numb fingers just INSTANT .... If it...
  28. O

    Hypothalamic PVN, autonomic dysfunction and limbic system theory

    https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1381-4 The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity of the brain’s resident immune cells, microglia. Here we used [11C]DPA-713 and...
  29. O

    ME/CFS in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms...

    https://selfhacked.com/blog/natural-ways-to-increase-calcitrol-and-vitamin-d-receptor-gene-expression/
  30. O

    Astrocytes Regulate Breathing Rhythms

    Astrocytes, ‘caretaker’ cells that surround and support neurons in the brain, play a much more important role in circadian rhythms, the body’s 24-hour internal clock, than previously understood. The Medical Research Council (MRC)-funded study published today in the journal Science, found that...