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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. sveinnb

    Immune complex meditated pathology in ME/CFS - low grade complement activation symptoms

    Well here is the big caveat since we are not taking about traditional inflamation of swelling, redness and tissue damage. That kind of inflamation would increase the numbers of neutrophils not decrease them. Cortisteriod therapy works wonders on that. This is more on a chemokine/cytokine...
  2. sveinnb

    Immune complex meditated pathology in ME/CFS - low grade complement activation symptoms

    Thanks for pointing me to Primary Biliary Cholangitis. I agree there are definite similarities. The thing with traditional antibodies is that they will in almost all cases cause tissue injury and that is how they initially get detected. Majority of ME/CFS do not have any confirmed tissue injury...
  3. sveinnb

    Immune complex meditated pathology in ME/CFS - low grade complement activation symptoms

    Thanks for the input ellie84. I actually think that with this illness lowered values but in range is enough to cause symptoms. Antibody to antibody immune complexes are probably the smallest particles that can circulate your bloodstream but they still need to be cleared out and when that happens...
  4. sveinnb

    Immune complex meditated pathology in ME/CFS - low grade complement activation symptoms

    Dear all I would like to share some thoughts of mine and get your opinion. In my five year personal research I have come to suspect that myself and probably a subset of ME/CFS patients can trace their symptoms to constant low grade complement activation induced by immune complex creation...
  5. sveinnb

    Low neutrophils and high RF factor – help needed for diagnostic and treatment

    Dear friends Last March I caught a cold that left me in bed for a week. I had a sore throat all the way down to my right lung, headache, bone aches but no fever. Since then I have more or less been nonfunctioning. My physical level is maybe a quarter of it used to be and I have constant brain...