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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. S

    COMT, MAO, CBS, VDR, MTRR, where to start?

    And I was advised to take ~250 mg/day of activated charcoal. Again, helpful or harmful? I'm trying to clear stress hormones and excess estrogens. I have poor phase 2 liver detox due to methylation issues. I cannot afford to feel worse/more depleted. If I take it I'll space it out many hours away...
  2. S

    COMT, MAO, CBS, VDR, MTRR, where to start?

    Great...but it's supposed to help CFS and mito fxn, no? I don't know what to believe anymore. I think we're all so individual...how are we to tell if something will help or hurt us? Thank you, UM MAN.
  3. S

    COMT, MAO, CBS, VDR, MTRR, where to start?

    Hi, I recently ran my 23andme data through the Neurological Research Institute tool. Here are my pertinent results: SNP Gene Variation Result Call RS4680 COMT V158M +/- AG RS4633 COMT H62H +/- CT RS731236 VDR Taq TT AA RS2228570 VDR Fok FF GG RS6323 MAO A R297R +/- GT RS1801394 MTRR A66G +/+...