• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Search results

  1. Gondwanaland

    Anybody with ME/CFS also positive for glucose-6-phosphate dehydrogenase deficiency?

    Here is a 2023 state-of-the-art publication about this: (the supplemental file is a spreadsheet with all variations analyzed so far) https://www.sciencedirect.com/science/article/pii/S0002929723000034 Volume 110, Issue 2, 2 February 2023, Pages 228-239 Journal home page for The American...
  2. Gondwanaland

    Anybody with ME/CFS also positive for glucose-6-phosphate dehydrogenase deficiency?

    23andme lists 7 rs SNPs for us He carries one with decreased function and I carry another one
  3. Gondwanaland

    Anybody with ME/CFS also positive for glucose-6-phosphate dehydrogenase deficiency?

    Wait wait wait, just now I understand It is an X-linked gene So obviously men only carry one allele So I must look into this one allele! 🤦‍♀️😬😅
  4. Gondwanaland

    Anybody with ME/CFS also positive for glucose-6-phosphate dehydrogenase deficiency?

    G6PDD Glucose-6-phosphate dehydrogenase deficiency (several studies published about polymorfisms from Mediterranean, African and SE Asian continents) ≠ Glucose-6-phosphate dehydrogenase allele deletion (I am having a hard time in finding studies on this) My husband carries a G6PD allele...
  5. Gondwanaland

    Anybody with ME/CFS also positive for glucose-6-phosphate dehydrogenase deficiency?

    https://www.sciencedirect.com/science/article/pii/S0163725820303193 Pharmacology & Therapeutics Volume 222, June 2021, 107788 Current investigations on clinical pharmacology and therapeutics of Glucose-6-phosphate dehydrogenase deficiency
  6. Gondwanaland

    Anybody with ME/CFS also positive for glucose-6-phosphate dehydrogenase deficiency?

    I find this info very confusing, because it must be surely underestimated!
  7. Gondwanaland

    Gilbert's Syndrome

    My point is that the conditions below, alone or combined, can be present and asymptomatic. However, chronic fatigue and exercise intolerance can be triggered by -infections -injury -medications for infections and injuries -poor lifestyle (esp. alcoholism and smoking) -fasting -strenuous exercise...
  8. Gondwanaland

    Gilbert's Syndrome

    https://doi.org/10.1136/dtb.2018.000028 Overview of Gilbert’s syndrome Differential diagnoses Other causes of unconjugated hyperbilirubinaemia - Haemolysis - Autoimmune haemolytic anaemia - Glucose-6-phosphate dehydrogenase deficiency - Sickle cell disease - Thalassaemia - Hereditary...
  9. Gondwanaland

    Gilbert's Syndrome

    I recommend to those who have found increased bilirubin levels (even 0.1 below the top range in anyone of the three bilirubin markers (total bilirubin, unconjugated bilirubin, conjugated bilirubin), or have found homozygosity in 23&me for anyone of the genes in the UGT gene family to also check...
  10. Gondwanaland

    Majority of doctors unaware of Black Box warnings on drugs they prescribe - we can't rely on them for info, have to educate ourselves

    For instance: https://www.healthline.com/nutrition/g6pd-deficiency-foods-and-supplements-to-choose-and-avoid People can live over 50 years and never know about their condition, which can be suddenly aggravated by an infection or injury. If they do not present with anemia, the health...
  11. Gondwanaland

    Majority of doctors unaware of Black Box warnings on drugs they prescribe - we can't rely on them for info, have to educate ourselves

    High bilirubins mean impaired xenobiotic detoxification! Some conditions upstream to it are (heterozygous from the X chromosome) deletions in the genes G6PD and GST, that may lead to and/or be associated with (autossomal homozygous) Gilbert's and Rotor's syndromes (heterozygosity also has an...
  12. Gondwanaland

    Majority of doctors unaware of Black Box warnings on drugs they prescribe - we can't rely on them for info, have to educate ourselves

    Additionally, I strongly recommend to anyone considering to take medications, herbs or supplements to check their levels of fasting bilirubin first. If any one or more than one of the markers (total bilirubin, unconjugated bilirubin, conjugated bilirubin) is slightly elevated or at the top end...
  13. Gondwanaland

    Worse or better after menopause?

    All is well, thanks! Ups and downs, learning and biohacking too!
  14. Gondwanaland

    My Recovery From CFS (1): First Thing First

    Looking forward to reading your musings, findings and conclusions!
  15. Gondwanaland

    Fungal issues since starting methylation

    Taking B vitamins can deplete Zinc and Vitamin C, which help in the modulation of the immune system.
  16. Gondwanaland

    Gilbert's Syndrome

    https://www.sciencedirect.com/science/article/pii/S016882782300421X Journal of Hepatology Volume 79, Issue 4, October 2023, Pages 1049-1055 Review Gilbert’s syndrome revisited Summary Gilbert’s syndrome, also known as benign hyperbilirubinaemia, was described more than 100 years ago. It has...
  17. Gondwanaland

    Gilbert's Syndrome

    I found this nice paper with nutritional recommendations tailored to specific liver enzymes (incl. GS' UGT1A1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488002/pdf/JNME2015-760689.pdf Review Article Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components...
  18. Gondwanaland

    Unfolded Protein Response and A Possible Treatment for CFS

    In addition to Fib-4 there is another calculator: https://www.hepatitisc.uw.edu/page/clinical-calculators/apri AST to Platelet Ratio Index (APRI) Calculator This is an AST to Platelet Ratio Index (APRI) calculator tool. Enter the required values to calculate the APRI value. The APRI Score will...
  19. Gondwanaland

    COVID can infect dopamine neurons, causing neuron senescence, and potentially brain fog and depression. But 3 drugs can rescue these infected neurons

    Could this be the reason? https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-014-0082-4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304344/
  20. Gondwanaland

    Unfolded Protein Response and A Possible Treatment for CFS

    What is your opinion about it? Does it underestimate it or is it pretty much accurate?
  21. Gondwanaland

    Unfolded Protein Response and A Possible Treatment for CFS

    @mariovitali did you know that there is an online calculator to estimate the degree of liver fibrosis called fib-4?
  22. Gondwanaland

    Unfolded Protein Response and A Possible Treatment for CFS

    perhaps there are some answers in the study I highlighted above?
  23. Gondwanaland

    Does anyone else have an extremely exaggerated startle response? Need help with this.

    Chris Masterjohn talked about it recently and found that a glycine deficiency would be the underlying cause. https://chrismasterjohnphd.substack.com/p/startled-try-glycine
  24. Gondwanaland

    Newly identified pathway provides insight into long COVID brain fog

    I never figured out why picolinate was so bad https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1742-4658.2012.08551.x
  25. Gondwanaland

    Newly identified pathway provides insight into long COVID brain fog

    I had forgotten I tried Zn Carnosine as well (Stomazinc) and it is very unhelpful that carnosine breaks down into alanine and histamine.... Not sure if starting with magnesium will be helpful, in my case taking Zn successfully was essential to unlock B6 metabolism and then be able to take...