• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. Lassesen

    ME/CFS is a mystery no more! Under ME/CFS hides Chronic Bacterial Intoxication Syndrome (CBIS) — [This Thread ONLY for Posting Questions to Dr Markov]

    I've done a review.. Their results are creditable, their treatment is creditable — their model may not be It is just an alternative path to the same goal -- changing the bacteria in the body that is causing ME/CFS. They found the bacteria include combinations of ( enterococci...
  2. Lassesen

    Intro to the Microbiome for Medical Professionals

    The numbers of PubMed studies on the human microbiome have exploded in the last few years as shown in the chart below. In the early 1990’s we had around 10 studies a year. In 2017 we reached 4421 studies — a massive increase and expect at least 4000 every year going forward. This creates a...
  3. Lassesen

    Science based mouth wash for ME/CFS

    This post comes out of a 2018 article: Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function. [Sep 2018]. The basic findings was: Of these, Veillonella abundance was significantly different between CFS patients and healthy controls, with 9.81 ±...
  4. Lassesen

    Comment by 'Lassesen' in 'Seed Probiotics – After one month, Persistence may occur'

    Those are random mixtures of bacteria that will vary from one batch to the next. One batch may help and the next make worst. I prefer to know precisely which bacteria that I am taking.
    • Lassesen
    • Blog entry comment
  5. Lassesen

    Seed Probiotics – After one month, Persistence may occur

    I just got my ubiome results today. The sample was taken after one month on Seed Probiotics. I believe that the Seed Probiotics have made a significant positive impact on me, but the impact that I was most hoping for was seeing more lactobacillus AND bifidobacterium being reported. The answer...
  6. Lassesen

    Comment by 'Lassesen' in 'ME/CFS with and without IBS Microbiome'

    My best suggestion is to get a ubiome explorer test done (direct retail, no MD involvement) and upload the results to my (free) site. http://microbiomeprescription.azurewebsites.net/upload/ubiome The data goes into an artificial intelligence system loaded with some 80,000 facts and comes out...
    • Lassesen
    • Blog entry comment
  7. Lassesen

    Fourth ubiome report on ME/CFS Flare progression: Improvement!

    Recap of this Journey For new readers: I have had Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) three times in my life and recovered each time. As a result of work stress, I am currently in a ‘flare’, because it was sudden onset and I realized what it was on day one and took...
  8. Lassesen

    Predicting Symptoms from microbiome lab reports

    This item has been on my backburner for a while and today I came up with an efficient algorithm to compute a short most probable symptoms. The results on my own samples were actually quite accurate. I have MTHFR issues (reported by conventional testing), this is my age range, cold hands and...
  9. Lassesen

    ME/CFS with and without IBS Microbiome

    Doing a few more hours of reviewing PubMed studies, I came across “Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome” [2017] There were some interesting findings. Increased abundance of unclassified Alistipes and decreased...
  10. Lassesen

    Anyone else crash out with new probiotic?

    The reference https://cfsremission.com/2016/11/21/just-thrive-probiotics-update/
  11. Lassesen

    Anyone else crash out with new probiotic?

    Risk of HISTAMINE reaction. Many histamine producers in it.
  12. Lassesen

    Suggestions to minimize impact of Drugs and Antibiotics

    A friend asked about how to modify their diet to minimize the impact of doxycycline. I had an old page on that but discovered that it was both broken and inconsistent with revisions and new features. I have brought it up to standards. Process Step 1: Find the Drug Antibiotics Other Drugs For...
  13. Lassesen

    Comment by 'Lassesen' in 'Is your gut bacteria producing enough vitamins - if not, which one are short?'

    The difference is which bacteria you include (there is no definitive list), and whether you have information on relative production. For example: You have 1000 of X that produces, but only at 30% of the best one. On one system that may be 1000 units on the other system 300. I have some items...
    • Lassesen
    • Blog entry comment
  14. Lassesen

    Comment by 'Lassesen' in 'A very very unusual probiotic mixture that is just coming on to the market'

    One label was pre-first-shipment, they may have discovered that they could pack into 2 instead.
    • Lassesen
    • Blog entry comment
  15. Lassesen

    Seeing the species that may need correction

    Some readers have requested that I show the list of bacteria that were selected to make suggestions from. I have done some refactoring and they are now available from three different ways of selecting bacteria that are available on the site now. Reports go down to the strain in some cases...
  16. Lassesen

    Getting custom suggestions from 16s Results (ubiome)

    There is a lot of uncertainty in modifying an ill microbiome. This starts with selecting the bacteria you want to change, see this post Steeing the species that may need correction to whether something actually modifies a bacteria without causing undesirable side-effects. You cannot be blinkered...
  17. Lassesen

    Is your gut bacteria producing enough vitamins - if not, which one are short?

    I have added a new page today that shows the relative production of various vitamins and a few metabolites compared to a healthy population. It is linked to from the samples page. Each sample will give different results The regular suggestions pages may list these vitamins because it is known...
  18. Lassesen

    The Rosetta Stone for treating symptoms

    This week I applied an old technique to microbiome analysis which I remember using to solve some messy problems that I was dealing with professionally back in 1982. The solution was to return to the question or assumption without going down the path mostly travelled. Almost all of the microbiome...
  19. Lassesen

    Eureka! Specific bacteria are associated with specific conditions and symptoms!

    I have just pushed a new update to the http://microbiomeprescription.azurewebsites.net/ website. The new page lists bacteria associated with specific symptoms and conditions. Finding Gender specific bacteria shown above agrees with research Right Thinking Almost all published studies report...
  20. Lassesen

    Comment by 'Lassesen' in 'A very very unusual probiotic mixture that is just coming on to the market'

    I have also received mine and can definitely feel positive effects and a much better sense of well being. In two weeks, I will be doing a ubiome and I am curious to see what impact it has. I did a ubiome a few days before starting it.
    • Lassesen
    • Blog entry comment
  21. Lassesen

    What is human sourced probiotics and why do we care

    If you look at different strains of a probiotic such as Lactobacillus Reuteri and dig far enough into research papers — you will see charts like the one below. From prediction to function using evolutionary genomics: human-specific ecotypes of Lactobacillusreuteri have diverse probiotic...
  22. Lassesen

    Comment by 'Lassesen' in 'A very very unusual probiotic mixture that is just coming on to the market'

    My wife has been on it for 6+ months, and swears by it --
    • Lassesen
    • Blog entry comment
  23. Lassesen

    Comment by 'Lassesen' in 'A very very unusual probiotic mixture that is just coming on to the market'

    It is still pre-order -- has not shipped yet.
    • Lassesen
    • Blog entry comment
  24. Lassesen

    A very very unusual probiotic mixture that is just coming on to the market

    In general, I prefer single species or single strain probiotics that has studies on PubMed. On occasion, a probiotic mixture makes it to my “second line probiotics to try”. There is a new pair on the market (one for men, one for women) that passes the bar. What is my bar? All of the strains...
  25. Lassesen

    Excellent template for work or insurance documentation of ME/CFS

    I have been on long term disability for ME/CFS, had to deal with school boards for children with ME/CFS and often seen ad-hoc reports created by well meaning MDs. These situations are often legal situations and not medical treatment scenarios — I have seen reports missing the mark — often...
  26. Lassesen

    Comment by 'Lassesen' in 'Treating myalgic encephalomyelitis with little information'

    From https://histaminentzug.de/die-10-besten-probiotika-bei-histaminintoleranz/
    • Lassesen
    • Blog entry comment
  27. Lassesen

    Treating myalgic encephalomyelitis with little information

    Myalgic encephalomyelitis is a complex disease, likely the most complex known by several magnitudes. The symptom list is massive. Looking for clustering at the patient level finds a vast array of sensitivities that makes one plan for everyone impossible, but even a dozen plans are improbable to...
  28. Lassesen

    Comment by 'Lassesen' in 'A IT Reader’s Medical Challenges'

    Yes, and also lumbrokinease and serrapetase. They are my 'trinity'
    • Lassesen
    • Blog entry comment
  29. Lassesen

    What does the onset of ME/CFS look like with the microbiome over the first 6 days!

    I just received my uBiome report for a sample taken 6 days after a sudden onset ME flare. It was sudden onset because over 15 minutes I could feel my entire body shift and booked off sick for the rest of that day (and following week). The cause was stress, the cause of 40% of ME cases according...
  30. Lassesen

    A IT Reader’s Medical Challenges

    I usually avoid getting too involved with readers — for a simple reason: this blog and the microbiome analysis site is already a time consuming evening and weekend gig (full time IT day job). I am not a physician or medically trained, so “patient history” is an inappropriate term to use. This...