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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. jadeoboe

    adding SAM-e and TMG

    Ok Freddd I understand now....I have ordered some l-carnitine fumarate and Dibencoplex. I have tried many different sublinguals including the 5 star ones but only felt something from the nasal spray - I feel like this is really powerful, the day after starting it I experienced greater mental...
  2. jadeoboe

    adding SAM-e and TMG

    So are you saying Freddd that SAMe and TMG are not long-term solutions? I'm desperate to feel better - I have had moments of clarity and 10% improvement but these have only lasted a day or 2. Taking 6mg Metafolin and MethylMate B12 spray as well as P-5-P but seem to be feeling worse now, sort of...
  3. jadeoboe

    adding SAM-e and TMG

    Thanks Freddd - what is your opinion on dose of SAMe, do I stay at 400mg or increase after say 2 or 3 weeks if no effect?
  4. jadeoboe

    adding SAM-e and TMG

    Hi All I am going to try taking SAM-e and TMG to augment the methylation protocol to see what effect it has, I know Freddd has mentioned them before with SAM-e at a dose of 400mg - is this dose fixed or does anyone ever need more than that? I'm not sensitive to supplements and always need...
  5. jadeoboe

    New here - methyl trap? Low B12? Please help!!

    Thank you very much everyone for your kindness in offering your ideas, I will have a think what to do next....
  6. jadeoboe

    New here - methyl trap? Low B12? Please help!!

    Oh forgot to add, I also have really bad nausea which comes on after taking folate!
  7. jadeoboe

    New here - methyl trap? Low B12? Please help!!

    Hello everyone - this is my first post but I've learnt so much from all the incredibly knowledgeable people on this forum which prompted me to self-treat...I suspect MTHFR but have not been tested, my symptoms started when I began the contraceptive pill 20 years ago and never went away even on...