Alzheimer's and Innate Immunity in the Brain

[Learner1]

This made the news today. Two scientists at Mass General think amyloid beta is part of the brain's innate immune system.

https://www.npr.org/sections/health...n-alzheimers-and-brains-ancient-immune-system

 

[Hip]

That makes a lot of sense from the herpes simplex virus brain infection theory of ME/CFS.

Maybe the beta amyloid protein is just trying to protect the brain from HSV-1.


This study found that in most Alzheimer's disease brains, the amyloid plaques contain HSV-1 DNA, and 72% of the total HSV-1 DNA in the brain was associated with these plaques.

Whereas in normal aged brains, which contain amyloid plaques at a lower prevalence, 80% of plaques contained HSV-1 DNA, but only 24% of the total HSV-1 DNA in the brain was plaque-associated.

 

[Learner1]

Its also bacteria and fungi, as discussed in this thread:

http://forums.phoenixrising.me/inde...bacteria-than-healthy-ones.52972/#post-878302

 

[jpcv]

Very interesting, I had already read about it at The excellent blog Microbeminded, there is a interview with Moir.
Microbeminded is written by Amy Proal, a ME patient.
There is an intererview also with the researcher that proposed the Vagus nerve theory Of the etiology of ME. It's worth a reading.

 

[Hip]

I actually wrote to the research team looking into HSV-1 etiologies of Alzheimer's some while ago, and told them about Dr Pridgen's Famvir + celecoxib protocol for targeting HSV-1 in fibromyalgia.

They said they would love to conduct a trial of HSV-1 antivirals for Alzheimer's, but cannot get funding, because very few experts in the world of Alzheimer's research believe that Alzheimer's could be caused by infections, so their grant applications get turned down by these experts.

 

[keenly]

Alzheimer's is a light story.