hm. Does that mean when you take cream your body decides how much allpregnanolone it will make but when you take ORALLY a lot of it is converted to allpregnanolone? Because I remember when I took progesterone orally I really noticed the calming effect. the cream yes it has helped me calm down but not as much as when I took orally but my cream dosage is also a lot lower, when I took it orally the dosage was pretty high. But cream does help with my sleep definatly.. So IDK what to think. Maybe I need to up my dosage from 20mg cream or maybe the cream progesterone hasnt kicked in fully yet? im 3 days in.
What progesterone dose did you take orally? If it is a lot higher than your transdermal cream dose, then you cannot really compare.
Interesting though that oral progesterone is better than transdermal for creating allopregnanolone. It confirms that
here:
while oral progesterone is not a good way to get progesterone into the body, it is a great way to get allopregnanolone in the body.
Instead of using progesterone, you can also take
5α-dihydroprogesterone (5α-DHP), which is a direct precursor to allopregnanolone. 5α-DHP can be bought
here, as a "research chemical".
The creation of allopregnanolone from progesterone following this pathway:
Progesterone ---(5AR)---➤ 5α-dihydroprogesterone ---(3α-HSD)---➤ allopregnanolone
5AR is the enzyme 5-alpha-reductase.
There is some interesting info on allopregnanolone
here.
This article says:
Allopregnanolone (also known as Allo) is a neurosteroid found in the brain and bloodstream. In previous studies it has shown promise as a potential regenerative therapy to promote brain cell creation (neurogenesis) and improve cognitive function in older animals and animals with induced Alzheimer’s disease.
And a pharmacuetical comapny is working on a synthetic and more powerful version of allopregnanolone called
ganaxolone.
The cream not doing anything for bones is wrong ,im proof of it. My teeth are stronger, wrists stronger.. and im just few days in.
I don't think a feeling of wrist strength will come from increased bone strength, and in any case, there is no way your bone strength is going to increase in just a matter of days. Likewise for teeth.