A.B.
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Unexpected new lung function discovered: Making blood
- Thread starter A.B.
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anciendaze
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Please note that marked cells introduced in the lungs of mice deficient in thrombocytes (thrombocytopenia) also showed up in bone marrow. There must be traffic in both directions, and not simply biochemical signalling.
"Glowing cells from the transplanted lungs soon showed up in the bone marrow, where they helped to produce not just platelets, but also other key blood cells like neutrophils, B cells and T cells."
Anyone out there able to find even a suspicion of this channel of information flow about the immune system in medical textbooks?
Platelets (thrombocytes) play a central role in control of bleeding, and I've repeatedly suggested that either ischemia or bleeding could result in sterile cell death which could cause an autoimmune response, since there would be no pathogen to blame.
This finding will need to be replicated in humans, and it won't be possible to engineer humans with platelets that glow in the dark. Still, I think this is an important line of investigation for mysterious lingering effects of pulmonary infections, and many doctors will testify that they don't understand why a course of antibiotics often fails to reverse progress of as well-known an infectious disease as TB. For diseases where immune response has become autoimmune, or is somehow deranged into attacking harmless infectious agents, this presents an entirely new line of investigation.
It may also be relevant to chronic diseases with severe "flu-like symptoms" at onset.
"Glowing cells from the transplanted lungs soon showed up in the bone marrow, where they helped to produce not just platelets, but also other key blood cells like neutrophils, B cells and T cells."
Anyone out there able to find even a suspicion of this channel of information flow about the immune system in medical textbooks?
Platelets (thrombocytes) play a central role in control of bleeding, and I've repeatedly suggested that either ischemia or bleeding could result in sterile cell death which could cause an autoimmune response, since there would be no pathogen to blame.
This finding will need to be replicated in humans, and it won't be possible to engineer humans with platelets that glow in the dark. Still, I think this is an important line of investigation for mysterious lingering effects of pulmonary infections, and many doctors will testify that they don't understand why a course of antibiotics often fails to reverse progress of as well-known an infectious disease as TB. For diseases where immune response has become autoimmune, or is somehow deranged into attacking harmless infectious agents, this presents an entirely new line of investigation.
It may also be relevant to chronic diseases with severe "flu-like symptoms" at onset.