You can say the first trigger "awakens" the real problem. This view explains spontaneous remission of symptoms as the real problem fluctuates from "asleep" and "awake".
A purigenic signaling problem can't explain spontaneous remission and relapses. A danger going back and forth from hidden to present explains it.
I really can't pretend to understand what you are talking about as I don't have any kind of science background - couple that with brain fog, neuro issues and acquired Dyslexia and I am scratching my empty head. However you have piqued my interest by brining up the issue of remissions and relapses. I myself had a long, spontaneous remission to nearish normal (I could exercise but didn't have others stamina. I had 4 kids and ran around with them all day, but couldn't add in working as well etc)
This lasted approximately 8 years, during which time I believed myself to be 'cured' of M.E. It was a measles infection, picked up from my children in 2008, followed by Pneumonia that lead to a return of all M.E symptoms that has never abated and is more severe than before. I am now severe to moderate severe, as it fluctuates slightly. Apart from the odd day here and there and 6 weeks last year after lots of IV glutathione and myers cocktails I have remained severely ill.
I know there are others of us who have had remissions and then 'relapses'.
@Rose49 - do you know if Ron is aware of this cohort of people? My symptoms are classic ME by any criteria (I took part in a De Paul study that confirmed this). I have also been a patient of Dr.Myhill who confirms severe M.E with mito issues as per her work and a patient of KDM who also confirms M.E (with chronic bacterial infections and gut issues).
@Ben Howell - how could the CDR mechanism explain this group of people?
