- Messages
- 17
- Location
- Northeast US
Hi All,
This post is regarding my life long struggle with what I believe is excess histamine production. I have always had the symptoms, hives (I used to get this with just stress), allergies, anxiety, inflammation, itchy skin (in dry weather this turns into rashes and my hands / feet peel, again I believe this is histamine release due to low moisture in the air), mild adult acne, although I control it to keep it mild (it can be triggered by high protein / histamine foods or sex), excess saliva, lean / fast digestion
I am also homozygous for MTRR A66G (GG) and VDR TAQ (AA) / heterozygous for COMT V158M and H26H; I recently started a methylation protocol to combat my MTRR, started with 1mg twice a day of mB12 for 4 weeks, then bumped up to once a day 5mg mB12 along with 800mcg mfolate. I also eat healthy and organic, no hydrogenated fats, whole grains, free range, greens etc.
I was hoping the mB12 would be the key to reduced histamine, but for the most part I still have the high histamine symptoms. From further reading I am thinking the methylation may only slightly help my high histamine and perhaps it is caused by something else, maybe DAO issues and the wrong bacteria / flora in my gut
I seem to be okay with yogurt and milk, but most cheeses, cottage cheese, canned tuna, tuna fish salad, whey protein isolate powders, canned salmon will trigger cystic like acne.
On to my questions:
1. Why did the mB12 and mFolate not reduce histamine symptoms, could this be due methylation not being the root cause in my case?
2. The 5mg mB12 makes me irritable and at times more anxious, could this be because my COMTs (i.e. my body has all the methyls it needs, and COMT will reduce my neurotransmitter breakdown)? Please elaborate on this, especially if you have experience with these SNPs or symptoms
3. Histadelics are supposed to be undermethylators, however I have anxiety and at times depressive / emotional episodes, overall am sensitive. My question is, how can one be an undermethylator and have anxiety? I believe folks like Dr Lynch say its should always be the opposite?
4. Can anxiety be triggered by excess dopamine and / or excess epinephrine / adrenaline? Perhaps I am an undermethylator but get anxiety for a different reason, maybe histamine driven?
Any support and feedback is much appreciated, please share your experiences as well!
Thanks
This post is regarding my life long struggle with what I believe is excess histamine production. I have always had the symptoms, hives (I used to get this with just stress), allergies, anxiety, inflammation, itchy skin (in dry weather this turns into rashes and my hands / feet peel, again I believe this is histamine release due to low moisture in the air), mild adult acne, although I control it to keep it mild (it can be triggered by high protein / histamine foods or sex), excess saliva, lean / fast digestion
I am also homozygous for MTRR A66G (GG) and VDR TAQ (AA) / heterozygous for COMT V158M and H26H; I recently started a methylation protocol to combat my MTRR, started with 1mg twice a day of mB12 for 4 weeks, then bumped up to once a day 5mg mB12 along with 800mcg mfolate. I also eat healthy and organic, no hydrogenated fats, whole grains, free range, greens etc.
I was hoping the mB12 would be the key to reduced histamine, but for the most part I still have the high histamine symptoms. From further reading I am thinking the methylation may only slightly help my high histamine and perhaps it is caused by something else, maybe DAO issues and the wrong bacteria / flora in my gut
I seem to be okay with yogurt and milk, but most cheeses, cottage cheese, canned tuna, tuna fish salad, whey protein isolate powders, canned salmon will trigger cystic like acne.
On to my questions:
1. Why did the mB12 and mFolate not reduce histamine symptoms, could this be due methylation not being the root cause in my case?
2. The 5mg mB12 makes me irritable and at times more anxious, could this be because my COMTs (i.e. my body has all the methyls it needs, and COMT will reduce my neurotransmitter breakdown)? Please elaborate on this, especially if you have experience with these SNPs or symptoms
3. Histadelics are supposed to be undermethylators, however I have anxiety and at times depressive / emotional episodes, overall am sensitive. My question is, how can one be an undermethylator and have anxiety? I believe folks like Dr Lynch say its should always be the opposite?
4. Can anxiety be triggered by excess dopamine and / or excess epinephrine / adrenaline? Perhaps I am an undermethylator but get anxiety for a different reason, maybe histamine driven?
Any support and feedback is much appreciated, please share your experiences as well!
Thanks