Possible Brain Biomarker for ME/CFS Found

[lansbergen]

@ osisposis,

Have you found any papers about hand-eye coordination?

 

[osisposis]

@ osisposis,

Have you found any papers about hand-eye coordination?

I haven't looked but well see what I can find. I also have problems there too.

 

[osisposis]

@ osisposis,

Have you found any papers about hand-eye coordination?

ok, I just grabed these cause they looked of interest, haven't read any, they may link to some other leads ?

Hand-Eye Coordination Improves Cognitive and Social Skills

Cognitive scientists at Indiana University have discovered a strong correlation between hand-eye coordination, learning abilities, and social communication skills. The study titled “Joint Attention Without Gaze Following: Human Infants and Their Parents Coordinate Visual Attention to Objects Through Eye-Hand Coordination," was published on November 13, 2013 in the online journal PLOS ONE.

The mysterious and powerful cerebellum (Latin: Little Brain) is only 10% of brain volume but holds over 50% of your brain’s neurons. My father, who was a neurosurgeon and neuroscientist always said, “whatever the cerebellum is doing, it’s doing a lot of it.”

In another study from March 2013, a research team honed in on the gene Tsc2 in Purkinje cells of the cerebellum and found that loss of Tsc2 in Purkinje cells lead to autistic-like behavioral deficits. These studies provide compelling evidence that Purkinje cell loss in the cerebellum and/or dysfunction may be an important link between ASD as well as a "general anatomic phenomenon that contributes to the ASD phenotype," according to researchers.

A 2001 study published in the journal Nature Neuroscience confirmed that the cerebellum coordinates eye and hand tracking movements. The researchers used functional magnetic resonance imaging (fMRI) during visually guided tracking tasks that required varying degrees of hand-eye coordination.

The researchers found that the cerebellum was more active during independent rather than coordinated eye and hand tracking. However, in three further tasks, they also found increases in cerebellar blood oxygenation as hand-eye coordination increased.

This proves that the cerebellum has a direct relationship to tracking performance, with high activity seen during both coordinated and independent conditions of hand and eye tracking. This data provides the most direct evidence that the cerebellum not only supports motor coordination but plays a significant role in learning to coordinate eye and hand movement.

Could the Vestibulo-Ocular Reflex be Linked to Autism?

The cerebellum also controls the vestibulo-ocular reflex (VOR) which is a reflex eye movement that stabilizes images during head movement by producing an eye movement in the direction opposite to head movement, which keeps the image in the center of your visual field. VOR is used for tracking a target and for helping to coordinate hand-eye movement. For example, when the head moves to the right, the eyes move to the left, and vice versa. Since slight head movement is present all the time, the VOR is very important for stabilizing vision.

Brain Connectivity Between Hemispheres is Key to Learning

Another study from August 2013 found that atypical visual orientation in 7-month-olds could be a sign of risk for autism. The study titled “White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism” was published in American Journal of Psychiatry. White matter in the corpus callosum connects the left and right hemispheres of your cerebrum.

Conclusion: Scaffolding for Brain Connectivity is Built in Toddlers via Hand-Eye Coordination

Research is mounting that creating strong connectivity between both hemispheres of the cerebrum and both hemispheres of the cerebellum holds the key for optimizing brain function throughout a lifespan.

http://www.psychologytoday.com/blog...dination-improves-cognitive-and-social-skills


Assessment. 2014 Mar 3. [Epub ahead of print]
Grooved Pegboard Predicates More of Cognitive Than Motor Involvement in Parkinson's Disease.
http://www.ncbi.nlm.nih.gov/pubmed/24590077

PLoS One. 2013;8(3):e58464. doi: 10.1371/journal.pone.0058464. Epub 2013 Mar 15.
Drawing from memory: hand-eye coordination at multiple scales.
http://www.ncbi.nlm.nih.gov/pubmed/23554894

Front Hum Neurosci. 2014 Sep 11;8:713. doi: 10.3389/fnhum.2014.00713. eCollection 2014.
Spectral convergence in tapping and physiological fluctuations: coupling and independence of 1/f noise in the central and autonomic nervous systems.
http://www.ncbi.nlm.nih.gov/pubmed/25309389

Front Psychol. 2014 Sep 25;5:1030. doi: 10.3389/fpsyg.2014.01030. eCollection 2014.
Long-range correlation properties in timing of skilled piano performance: the influence of auditory feedback and deep brain stimulation.
http://www.ncbi.nlm.nih.gov/pubmed/25309487


The Importance of Hand-Eye Coordination
Last Updated: Sep 28, 2010

http://www.livestrong.com/article/252448-the-importance-of-hand-eye-coordination/

http://www.emory.edu/EMORY_REPORT/erarchive/1996/November/ERnov.11/11_11_96brains_role.html

 

[osisposis]

ok, was a little distracted earlier, so did a little more looking, but didn't find much more, but gee, I've researched Autism alot because I always felt with the gut and brain issues there was so much in common and the more they figure out the more at least ME/CFS caused by WDB exposure is showing that we do and theres not doubt in my mind a aquired form of Autism could be caused by chemical/toxins exposures.

Atypical hemispheric asymmetry in the arcuate fasciculus of completely nonverbal children with autism

Catherine Y. Wan,
Sarah Marchina,
Andrea Norton and
Gottfried Schlaug

Article first published online: 23 APR 2012

DOI: 10.1111/j.1749-6632.2012.06446.x
http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06446.x/abstract

http://www.musicianbrain.com/papers...lHemisphericAsymmetry_AF_Autism_ANYAS2012.pdf


Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966943/


Review ARTICLE
Front. Integr. Neurosci., 09 April 2013 | doi: 10.3389/fnint.2013.00022
A review of “music and movement” therapies for children with autism: embodied interventions for multisystem development
http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00022/full

Autism papers
http://iacc.hhs.gov/events/2012/092812/iacc_articles_092812.pdf


Mild Mental Retardation with Indifferentiated SchizopreniaNCMH

(LISTED AS A CAUSE)
* Absence of in the brain of the arcuate fasciculus

http://www.scribd.com/doc/28504131/Mild-Mental-Retardation-With-Undifferentiated-SchizophreniaNCMH


-----------------------------------------

Functional connectivity changes in adults with developmental stuttering: a preliminary study using quantitative electro-encephalography
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195313/

 

[lansbergen]

@ osisposis, Thanks

 

[Dx Revision Watch]

http://www.nhs.uk/news/2014/10Octob...ences-linked-to-chronic-fatigue-syndrome.aspx

http://www.nhs.uk/news/2014/10Octob...ences-linked-to-chronic-fatigue-syndrome.aspx
NHS Choices | Behind the Headlines

Brain differences linked to chronic fatigue syndrome

Friday October 31 2014

"...The Mail Online's headline, "Is this proof chronic fatigue DOES exist?", casts doubt upon whether CFS actually exists. It's known CFS affects many thousands of people, with often severely debilitating consequences, so its existence is not in doubt."

 

[Dx Revision Watch]

@Jonathan Edwards -- Any thoughts on this study?

Yes, it would be interesting to hear Dr Edwards' thoughts, if he has the time.

 

[Cheesus]

I know this is an amazingly difficult question to answer, but how capable is the brain of healing this type of damage? Can it change back?

 

[Marco]

Effects of Practice and Experience on the Arcuate Fasciculus: Comparing Singers, Instrumentalists, and Non-Musicians

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133864/

A Review of Magnetic Resonance Imaging and Diffusion Tensor Imaging Findings in Mild Traumatic Brain Injury

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3803157/

Good find. Post concusssion syndrome is an interesting one given frequent symptoms of fatigue, cognitive problems, intolerance of stress, emotion and alcohol and exacerbation of symptoms following exercise :

Exercise Intolerance in Individuals With Postconcussion Syndrome

http://natajournals.org/doi/pdf/10.4085/1062-6050-48.5.02

If what had previously been dismissed as psychogenic due to an absence of evidence of persisting brain damage is now showing up as microstructural anomolies affecting white matter tracts using improved technologies - well there's hope for us yet.

 

[osisposis]

Good find. Post concusssion syndrome is an interesting one given frequent symptoms of fatigue, cognitive problems, intolerance of stress, emotion and alcohol and exacerbation of symptoms following exercise :

Exercise Intolerance in Individuals With Postconcussion Syndrome

http://natajournals.org/doi/pdf/10.4085/1062-6050-48.5.02

If what had previously been dismissed as psychogenic due to an absence of evidence of persisting brain damage is now showing up as microstructural anomolies affecting white matter tracts using improved technologies - well there's hope for us yet.

thank you , very interesting I've followed GWI on the TBI vs. PTSD , basicly the secondary immune responce with TBI is the same as the immune responce going on with PTSD making them hard to seperate, and theres a also a resent article finding that GWI is caused by toxin exposure. so at this point they just cant say that PTSD diagnoses is not in fact TBI and they cant really say it's all about just being in a extremely stressful situation anymore. the fact that both physicological and phycological stress involve the same pathways opens up to a whole lot more insight.

 

[osisposis]

@ osisposis, Thanks

Your Welcome

 

[Marco]

You're welcome. I'm interested in a group of multisystem/multisymptom syndromes that seem to follow a similar course with similar impairments in 'energetics', cognition, autonomic function etc. These include ME/CFS; GWI; post concussion syndrome and complex regional pain syndrome.

In all these cases the 'syndrome' develops in only a minority of cases exposed to the 'stressor' (whichever it is) and is 'disproportionate' suggesting that the host immune or immune/brain response triggers the syndrome.

 

[osisposis]

You're welcome. I'm interested in a group of multisystem/multisymptom syndromes that seem to follow a similar course with similar impairments in 'energetics', cognition, autonomic function etc. These include ME/CFS; GWI; post concussion syndrome and complex regional pain syndrome.

In all these cases the 'syndrome' develops in only a minority of cases exposed to the 'stressor' (whichever it is) and is 'disproportionate' suggesting that the host immune or immune/brain response triggers the syndrome.

yes, I also look at "like" diseases in my research, in WDB exposure there is a tipping point which involves a breakdown in tolerance, th1/th2 imbalance,IgG switching to IgE, MCS/both allergic and non-allergic hypersensitivities, loss of homeostates,ect. it goes beyond Shoemakers finding as from what I understand he does not include allergy or infection meaning his work basicly is pointing to IgG mediated effects only, complament and mast cells , I'm pretty confedent that this itself points to a seperation of ME and CFS.

 

[osisposis]

basicly this tipping point involves C4a, spent alot of time in immunology research, uggg! so anyways we have C4a inflammation going on , we have oxidative stress activating C4a, C4a causing mast cell degranulation, the evidence points to a deficency or dysfunction of C1-Inh (maybe receptor dysfunction ?) regardless, not only a this point does it point straight to allergic disease but also to autoimmunity, C4a than becomes a constant, probably low level but still with big increases when re-exposed to a trigger (plus), and at this point we are getting a double wammy on the mast cell effects which is where my research with Autism comes in pointing to much more severe damage. sorry, I have considerable problems with organization and also not only talking about what I know but putting together a comprehensive writeing to explain it, I'm slow and still type with one finger (hand-eye-brain!) but this hasn't made me stupied just very dysfunctional, might of even made me a little smarter in some way /QUOTE]

 

[osisposis]

and by the way, YES! to all here.

Exercise Intolerance in Individuals With
Postconcussion Syndrome

Table 1. Symptoms of Postconcussion Syndrome Assessed
Symptom Checklist
a
Head Injury Scale
b
Blurred vision Balance difficulty/dizziness
Dizziness Difficulty concentrating
Drowsiness Drowsiness
Excess sleep Fatigue
Easily distracted Feeling slowed down
Fatigue Feeling like
‘‘
in a fog
’’
Feel
‘‘
in a fog
’’
Headache
Feel
‘‘
slowed down
’’
Nausea
Headache Trouble falling asleep
Inappropriate emotions
Irritability
Loss of consciousness
Loss of orientation
Memory problems
Nausea
Nervousness
Personality change
Poor balance/coordination
Poor concentration
Ringing in ears
Sadness
Seeing stars
Sensitivity to light
Sensitivity to noise
Sleep disturbance
Vacant stare/glassy eyed
Vomiting


http://natajournals.org/doi/pdf/10.4085/1062-6050-48.5.02

 

[osisposis]

my research was based around a model without including any genetics but turned basicly into a model of possable immune deficiencies and so there would be possable variations just like many different variations in WDB's, but it's looked at as the worse the WDB the worse the injury, but there are some major differerences between a high moisture/humidity WDB situation and say one where theres drying between the wet episodes like a old victorian home with nothing but plaster and hard wood and dust, no insulation in the walls to hold moisture, anyways I didn't follow anyone doctor , my research was based around my experience in two WDB exposures that were very different. facts are, there are siuations where one could be exposed to just mainly Stachy, there is now 3 different types found, each affects a little different, I do believe that possably what Shoemaker is looking at is a exposure like this, now seems they stop just short of allergy and infection ( and may not have the severe sinus/brain damage like I didn't get from my first WDB home, I experienced only a stuffy nose there, nothing like what happened in the 2nd WDB), and a high moisture/humidity WDB brings more to the mix like high Voc's that play in with the sinus/brain damage, and also offgassing voc's from man made material exspecially in a bad remediation/remodel job, where more chemicals from paints,glues,carpets ect come in, this was my second WDB exposure and it truely did try to kill me, Asp/Pen, ++, basic tore up my airways and on, and sent my head to lalaland. ps , this just took considerable time for me to do this and try to correct obvious mistake and so on, JFYI

 

[Kati]

@osisposis, careful with abbreviations, because some of us don't have a clue what you're talking about.
WBD ???

 

[osisposis]

@osisposis, careful with abbreviations, because some of us don't have a clue what you're talking about.
WBD ???

sorry, WDB water damaged building

 

[osisposis]

Reading impairment in a patient with missing arcuate fasciculus

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671152/

 

[Valentijn]

Reading impairment in a patient with missing arcuate fasciculus

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671152/

She's also missing the left one, not just the right one, as well as having several other abnormalities following radiation therapy for brain cancer.