It seems that the name of the ingredient in this Allergy Research Russian choice rhamnosus lysate powder supplement is
Lactobacillus rhamnosus cell lysate, which is composed of peptides derived from the cell wall of Lactobacillus rhamnosus bacteria.
Another brand of the same product is Del-Immune V, and on
their website I found the following text:
Del-Immune V®: Born in Russia, perfected in America
In 1999, a cell wall formulation developed from Russian and Ukrainian research was brought to the United States by a retired Boulder, Colorado pharmacist. The pharmacist discovered that the lactobacillus cell wall product had a beneficial effect on his daughter’s hepatitis C symptoms when added to her supplement routine. What’s more, the product eliminated or improved several other health issues reported by friends and acquaintances. The pharmacist named the product “Del-Immune.”
In 2003, product manufacturing was moved from St. Petersburg, Russia to Vivolac Laboratories in Indianapolis, Indiana. Del-Immune’s potency and quality control were substantially enhanced through advanced American biotechnology. The pharmacist then renamed his American-made product “Del-Immune V®.” Today, Del-Immune V® is used by thousands of people in the United States and many other countries.
What is The difference between probiotics and Del-Immune V®?
The major difference between Del-Immune V® and conventional probiotics? Probiotics are live cultures; Del-Immune V® is a lysed product derived from these live cultures. “Lysing” is the central process. To make Del-Immune V®, Lactobacillus rhamnosus (DV strain) is cultured, then lysed – or broken apart with natural enzymes that are identical to those found in the human intestine. This creates cell wall fragments and pieces of DNA, the active components with special immune activators. The product mix is pulverized to produce a fine powder containing microscopic particles of cell wall fragments and other cell components.
The immune response activity takes place only when the lactobacillus cell is digested and broken into cell pieces. This entire process occurs naturally in the lower end of the small intestine and in the upper end of the large intestine.
Continuing and emerging research suggests that bacterial surface layer components from cell walls, when taken orally, enhance natural killer cell activity and increase the production of natural interferons which are known to attack bodily invaders that lead to illness.
The natural immune activation process from cell wall fragments provides resistance to infection that is non-specific, but also extends to environmental invaders, including seasonal infections. It is estimated that each capsule of Del-Immune V® contains more than 2 billion cell wall fragments to accelerate natural immune response.
Some research papers on Del-Immune V are found
here.
Some excerpts from these research papers are as follows:
➤ Research paper:
Del-Immune V Profile.
Del-Immune V Lactobacillus rhamnosus lysate stimulates the production of the cytokine line (IL-1), tumor necrosis factor (TNF-α), IL-2, IL-6, IL-8, IL-12 and gamma interferon (IFN-γ), which, in turn control production of Т-lymphocytes, В- lymphocytes, natural killer (NK) cells and phagocytes that coordinate the immune response, depending on the nature of the aggressive agent by Th1 or Th2 pathways respectively.
Note that several of the cytokines Del-Immune V stimulates (the ones I put in bold) are the Th1 cytokines, which of course are desirable for ME/CFS, as ME/CFS patients need to boost their Th1 cytokines in order to get better.
Just a quick reminder:
Th1 cytokines are: IL-2, IL-12, IFN-γ
Th2 cytokines are: IL-4, IL-10
➤ Research paper:
Study of Interferonogenous Activity of the New Probiotic Formulation Del-Immune V (A better pdf version of this document can be found
here.)
This study found that Del-Immune V Lactobacillus rhamnosus lysate induces interferon alpha and interferon gamma.
Del-Immune V demonstrated higher interferonogenous activity in vivo and in vitro than Bifidobacterium bifidum.
But although Del-Immune V induced higher levels of interferon than Bifidobacterium bifidum bacteria, presumably a Bifidobacterium bifidum probiotic might be almost as good as Del-Immune V?
It should be noted that gram-positive bacteria, including lactobacilli, activate the major class II histocompatibility complex, which induces IFN-γ and IL-12, which are necessary for Th1 differentiation of T-helpers.
Gram-negative bacteria and LPS (a major component of the cell wall of gram-negative bacteria; lipopolysaccharides are endotoxins and important antigens) induce monocytic production of IL-10, inhibiting cytotoxicity activation of IFN-γ and secretion by Т- and NK-cells.
➤ Analysis:
An Analytical Comparison of Del-Immune V® and Russian Choice Immune
The conclusion here is that there are some important differences between these two Lactobacillus rhamnosus cell lysate supplements:
•
Del-Immune V contained at least three times more protein than
Russian Choice Immune.
•
Del-Immune V contained more than 100 times the DNA than the
Russian Choice Immune capsules.
More info regarding the comparison of the two products:
Russian Choice Immune vs
Del-Immune V is found
here.
I also found this study:
Lactobacillus rhamnosus cell lysate in the management of resistant childhood atopic eczema.
This study found that Lactobacillus rhamnosus cell lysate provides a substantial improvement in eczema skin symptoms.