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Firestormm Thanks for the boost! Very exciting to see such positive research being done. Was at a mitochondrial disease lecture recently and sounds like some of the same things were being discussed there as well so maybe there really are some answers coming up in the future for us.
By "exercise" Julia Newton specifically said they were stimulating the muscle cells at a level that would replicate what ME/CFS patients would do in daily activity. Personally I would be thrilled if they came up with something that would relieve the muscle fatigue and pain that occurs when I try to function as that is one of my biggest limiting factors.
If they could figure a way to let me exercise again, I think that would be brilliant! Exercise was one of the things in my past life that I used to help deal with a lot of the other issues I had. If I could exercise again, I would be a very happy person.
You are welcome
Yes it was great to hear that even 'exercising' the muscle cells at a level that is believe to stimulate 'daily' activity i.e. not exercising them to their limit, they found clear abnormalities compared to controls and not all of it related to acid production, build-up and an inability to disperse.
I might transcribe as I hadn't heard these results before - hopefully a paper will be forthcoming shortly. If they can come up with something - a pill - that helps remove this damned muscle pain I experience even when at rest i.e. after movement and use of legs and arms - then I shall be a happy bunny.
How Julia's work that she describes relates to the 'fatigue' in general I don't know. I can't remember if she covered that in this presentation to be honest (yesterday was a long time ago for me to recall!).
She did talk about glucose, and energy production by muscle cells, and IL6 and something else I forget, and how differences were demonstrated again compared to controls. Quite how this might be treated, or why it was caused, she didn't say, but they are working on it too I guess.
There had been no promotion of this talk so it was something of a pleasant surprise - and boost - to hear the long-awaited results.
A very nice way to round off the day and no mistake - but blimey she took her time getting to the results didn't she? I was champing at the bit!
Not everyone - as she said - has these problems with muscle pain, aches, during or after exercise and at rest. Indeed she felt it was another means of determining sub-groups.
Muscle pain/ache is one of the more traditional associations with ME of course and it's a right pain in the arse to live with!
Anyway, I'm delighted to hear some positive news about this one: because painkillers only ever take the edge off the symptoms and you definitely cannot exercise them away and neither are they the result of inactivity - as has now been proven
Replication is ever necessary but it's studies like these that will break the camel's back.