Iritu1021
Breaking Through The Fog
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Learner1, I realized I skipped over your question to antibodies yesterday. H2 receptors are involved in antibody production. I've been through the whole "autoimmune theory" of POTS before and I didn't find it helpful. My impression was that in my sick states my body makes increased numbers of antibodies to literally everything - food, all viral antigens, thyroid tissue, etc. Whatever you test for, you are bound to find something. When there is poor tissue perfusion, there is going to be some tissue destruction, and any issue destruction generates antibody, and if you get too much histamine stimulation, the body just cranks up the volume of the production. According to Wikipedia, H2 (histamine) receptors inhibit antibody synthesis, T-cell proliferation and cytokine production antibody synthesis, and H4 receptors regulate mast cell chemotaxis.
The interesting question is why IVIG works in so many cases of both CFS and POTS. Could it be through helping to overcome the immune deficiency and defeat the pathogen within thyroid? It's one option. I always had low to moderate thyroid antibodies but large areas of inflammation on my thyroid ultrasound - so I'm more inclined to believe that the antibody generation was a secondary process next to viral infection that was going on in there. (There is now a strong link between EBV and autoimmune thyroiditis). Over the years the low level antibodies would probably add us to some real damage to cause true hypothyroidism.
That's just my interpretation at this point, hope it makes sense...
The interesting question is why IVIG works in so many cases of both CFS and POTS. Could it be through helping to overcome the immune deficiency and defeat the pathogen within thyroid? It's one option. I always had low to moderate thyroid antibodies but large areas of inflammation on my thyroid ultrasound - so I'm more inclined to believe that the antibody generation was a secondary process next to viral infection that was going on in there. (There is now a strong link between EBV and autoimmune thyroiditis). Over the years the low level antibodies would probably add us to some real damage to cause true hypothyroidism.
That's just my interpretation at this point, hope it makes sense...
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