Can anyone please help me work out what I need?
I have been treated by Dr and ND with methylb12 lozenges and hydroxy injections.
At present I'm taking a small amount of Methylfolate and methylb12 but feel dreadful some days and fine others. More makes me feel overmethylated and angry. I'm homozygous for MTR & MTRR & MAO I think high b12 intake without folate is dangerous as it will feed MTR which wants folate as well. My feeling is though that feeding this cycle in general is just pushing it all out the CBS pathway & generally leaving me undermethylated as I have no homocysteine to regenerate into methionine and create neurotransmitters etc. I do struggle with high sulphur & ammonia.
I have CBS SUOX & other snps just 1 MTHFR snp 1298c.
Also, after being treated by health professionals for methylation issues I have had chronic yeast infections (18mths now) which led to taking metronidazole during my last pregnancy close to delivery which I still very much regret due to the effects on my son's gut and our breastfeeding relationship.
Please help offer suggestions, should I be on hydroxyb12 only and food based folate or folinic acid only?
I have been treated by Dr and ND with methylb12 lozenges and hydroxy injections.
At present I'm taking a small amount of Methylfolate and methylb12 but feel dreadful some days and fine others. More makes me feel overmethylated and angry. I'm homozygous for MTR & MTRR & MAO I think high b12 intake without folate is dangerous as it will feed MTR which wants folate as well. My feeling is though that feeding this cycle in general is just pushing it all out the CBS pathway & generally leaving me undermethylated as I have no homocysteine to regenerate into methionine and create neurotransmitters etc. I do struggle with high sulphur & ammonia.
I have CBS SUOX & other snps just 1 MTHFR snp 1298c.
Also, after being treated by health professionals for methylation issues I have had chronic yeast infections (18mths now) which led to taking metronidazole during my last pregnancy close to delivery which I still very much regret due to the effects on my son's gut and our breastfeeding relationship.
Please help offer suggestions, should I be on hydroxyb12 only and food based folate or folinic acid only?