Split from the thread "Rituximab Phase III - Negative result"
I've mined the "transcription of Neil McGregor’s presentation at Open Medicine Foundation’s Community Symposium" i.e. on the Melbourne University website [MELBOURNE BIOANALYTICS]. He identified genetic variations among people with ME/CFS interestingly they highlight a link to virus's (RNA helicases & Langerin) and symptoms (G-proteins).
Question is how do we influence those who control the research budgets - NIH / European Commission / UK Government (£5 million plus for PACE)? E.g. European Commission has funded a fair bit research on diagnostic tests for Lyme's disease; they have a total budget of 80 billion euros (90 billion US dollars).
Extracts from transcription of Neil McGregor’s presentation:
"The 4th, 5th, 6th, & 7th clusters all involve RNA helicases. RNA helicases remove viral and bacterial RNA, and our host RNA, from the cell. These four clusters which had anomalies in RNA helicases, also had anomalies in some additional genes."
"RNA helicases are enzymes which remove double-stranded DNA, viral RNA and host RNA out of the cytoplasm. They are inhibited by viruses, and could potentially be the major reason for viral triggers in ME/CFS because, if there is a problem with RNA helicases, the body will have difficulty removing the viral RNA from the cell."
"From HIV studies, we know that when Langerin is inhibited, patients have greater viral loads, and more infections in the body."
"G-proteins are involved in a wide variety of processes in the body, many of which involve common symptoms in people with ME/CFS. Looking at the table on this slide, you can see the percentage ME/CFS patients in our sample who reported these symptoms. We think that some of these G proteins are critically important in symptom expression in ME/CFS."
Interestingly, none of that in my siblings/parents/ancestors nor myself, although could that be because these are relatively recent developments (I'm 60 and youngest sibling)? Then again, my son has hayfever and partner has IBD and coeliac. Could the latter point more to infectious agent?
All anecdotal of course, but such epidemiological data on a large scale might be very illuminating.
I've mined the "transcription of Neil McGregor’s presentation at Open Medicine Foundation’s Community Symposium" i.e. on the Melbourne University website [MELBOURNE BIOANALYTICS]. He identified genetic variations among people with ME/CFS interestingly they highlight a link to virus's (RNA helicases & Langerin) and symptoms (G-proteins).
Question is how do we influence those who control the research budgets - NIH / European Commission / UK Government (£5 million plus for PACE)? E.g. European Commission has funded a fair bit research on diagnostic tests for Lyme's disease; they have a total budget of 80 billion euros (90 billion US dollars).
Extracts from transcription of Neil McGregor’s presentation:
"The 4th, 5th, 6th, & 7th clusters all involve RNA helicases. RNA helicases remove viral and bacterial RNA, and our host RNA, from the cell. These four clusters which had anomalies in RNA helicases, also had anomalies in some additional genes."
"RNA helicases are enzymes which remove double-stranded DNA, viral RNA and host RNA out of the cytoplasm. They are inhibited by viruses, and could potentially be the major reason for viral triggers in ME/CFS because, if there is a problem with RNA helicases, the body will have difficulty removing the viral RNA from the cell."
"From HIV studies, we know that when Langerin is inhibited, patients have greater viral loads, and more infections in the body."
"G-proteins are involved in a wide variety of processes in the body, many of which involve common symptoms in people with ME/CFS. Looking at the table on this slide, you can see the percentage ME/CFS patients in our sample who reported these symptoms. We think that some of these G proteins are critically important in symptom expression in ME/CFS."
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