That looks like a good list of supplements to try to support blocked mitochondria. Which doses and brands have you found to be working for you?
I understand B1 might be important for PDH enzyme function (presumably blocked in ME). Do you take a specific form of B1? Does co-enzymated/bioactive versions of B1 exist?
Lipoic acid, that’s the same as ALA?
L Carnitine Fumarate?
In the multi b - does it include the P-5-P (B6) and 5-MTHF (B9)? Also is it B2 as R-5-P you take?
Creatine, I have tried the HCL variant (I think
@Hip recommended it). Did you notice improvements? It is supposed to “save” a lot of methyl groups (CH3) in the body.
Have you considered glutathion? Or read about someone who saw benefits from taking it wrt mito optimization?
Also, I am a bit bewildered by carb intake. Fluge Mella found that pyruvate oxidation seems to be reduced due to downregulation in PDH enzyme complex. Energy demands will increase glycolysis process in plasma (conversion of glucosis to pyruvate). This causes a buildup of pyruvate, and this will be converted to lactate (and maybe methylglyoxal?) - causing many of the PEM symptoms. So, my question is, are we somehow carb intolerant? Will eating too much (how much is too much for each of us?) carbs (glucose) cause a buildup of puruvate (hence lactate) in our cells, even if we are “idleing” (low energy demands in muscle, mentally and stresswise). Where would that glucose go if our cells cannot use it (PDH is blocked)? Or is it so that the PDH enzyme is only partially blocked (correlated to ME severity?) and that we can actually utilize a certain amount of carbs for energy production, but if we go over that “daily glucose limit” we get the malaise symptoms.
@Murph, you seem to have a pretty good overview of the latest research - any thoughts on this?
Also a bit sad to read in Fluge Mella paper that they also saw indication that ppl w ME might have problems utilizing fat as energy. I had believed that a Keto diet might provide some energy, since fatty acids convert to Aceryl-CoA directly, bypassing the PDH enzyme completely.
Edit: spelling..