knackers323
Senior Member
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If cfs can be caused by multiple triggers, which seems to be the case, and not just one single type of infection, then how are cfs outbreaks explained?
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Yes @Badpack your missing my point.
If its any virus, bacteria or fungus that we already know about that is causing cfs and not some new and undocumented 'cfs infection' these outbreakes should statisticly be much more common.
There is a discrepancy here between the two theorys
Theory one. Multiple triggers
Theory two. A single 'cfs infection'
If cfs can be caused by multiple triggers, which seems to be the case, and not just one single type of infection, then how are cfs outbreaks explained?
http://www.sciencedirect.com/science/article/pii/S1567724913002390The cell danger response (CDR) is an evolutionarily conserved cellular metabolic response that is activated when a cell encounters a chemical, physical, or microbial threat that could injure or kill the cell. Common microbial threats are viruses, bacteria, fungi, and parasites.
Physical threats include heat, salt, or pH shock, or UV or ionizing radiation. Chemical forms of danger include heavy and trace metals like lead, mercury, cadmium, arsenic, and nickel, certain electrophilic aromatic chemicals like the plasticizer bisphenol A, the chemical flame retardants like the brominated diphenyl ethers (BDEs), and certain halogenated pesticides like chlorpyrifos and DDT.
Psychological trauma, particularly during childhood, can also activate the cell danger response, produce chronic inflammation, and increase the risk of many disorders (Ehlert, 2013). Mixtures of these factors and susceptible genotypes have synergistic effects. The total load of triggers is integrated by metabolism and regulates the CDR.
Why no outbreaks since 1990 ?
I think that dr Dowsett's statement of a sevenfold increase in the incidence of ME during the 80s should be interpreted with some caution. She makes that statement in a short article on the webpage of the Hummingbird foundation. There is no epidemiological data to back up her assertion.
Large scale vaccination started in the 50s.
Evidence from several epidemics suggest spread by person-to-person contact and an incubation time of half a week up to a week.