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According to this, its not very stable in pill form.
Thanks for your post.whatever form is ingested, the body will convert it to methylcobalamin
Thanks for your post.
I'm still wondering why people are going to extra effort to find AB12, when MB12 is easier to find.
Effective marketing from quacks.I'm still wondering why people are going to extra effort to find AB12, when MB12 is easier to find.
That's not really an appropriate comment. Please keep such snarky comments to yourself.Effective marketing from quacks.
3) the citric acid cycle fails without the conversion of methylmalonyl CoA acid to succinylCoA (the reaction for which adenosylB12 acts as co-factor). It is true that if this reaction fails completely (such as in some rare genetic diseases) there are severe consequences, mainly because accumulating methylmalonic acid is toxic.
The absence of the reaction however doesn't stop the citric acid cycle since this pathway is used only for processing odd-chain fatty acids which are minor forms and a few amino acids; even-chain fatty acids, carbohydrate and most amino acids feed into the citric acid cycle independently of this reaction and keep the cycle going.
I appear to have a type of "methylmalonic acidemia" which I find is much improved when I take adenosylcobalamin but not so improved with methylcobalamin.
Of course, in these genetic diseases it's hard to know which specific pathways are disrupted and, unfortunately, this means one cannot always assume normal metabolic processes are taking place. I believe in normal metabolism adenosylcobalamin and methylcobalamin can be converted into the other. Do you know if this conversion is normally for very minor amounts? I am trying to understand my strong metabolic preference for adenosylcobalamin.
In the US and Europe, hydroxycobalamin has become the preferred treatment, rather than cyanocobalamin.
Hydroxo is difficult to find orally and in injectible in the US. I called 25 compounding pharmacies across the US and only 2 could fill a prescription for injectible hydroxo.I am not sure where you got the impression that hydroxocobalamin has become standard in the US. Cyano is still the most commonly prescribed form here. You can test this by simply walking into any ordinary pharmacy and asking if they even stock hydroxo. Most of them will tell you no. Hydroxo is the form prescribed in most of Europe though.
Hydroxo is difficult to find orally and in injectible in the US. I called 25 compounding pharmacies across the US and only 2 could fill a prescription for injectible hydroxo.
Most doctors think cyanocobalamin is the standard version and don't realize that some of us don't use it well, especially if high doses are needed.
It is available in the US, just a little hard to find.Maybe you could order it from Europe. I ordered it in Belgiuem maybe they ship to the U.S.
There‘s no special pharmacy I just ordered it from a pharmacy found in the internet.
I am not sure where you got the impression that hydroxocobalamin has become standard in the US.