Publication On Brain Lymphatic System

[Never Give Up]

https://elifesciences.org/articles/29738

 

[Never Give Up]

Here’s an NIH article about the path the researcher took in finding the lymphatic vessels:

https://www.nih.gov/news-events/news-releases/nih-researchers-uncover-drain-pipes-our-brains

By scanning the brains of healthy volunteers, researchers at the National Institutes of Health saw the first, long-sought evidence that our brains may drain some waste out through lymphatic vessels, the body’s sewer system. The results further suggest the vessels could act as a pipeline between the brain and the immune system.

“We literally watched people’s brains drain fluid into these vessels,” said Daniel S. Reich, M.D., Ph.D., senior investigator at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and the senior author of the study published online in eLife(link is external). “We hope that our results provide new insights to a variety of neurological disorders.”

 

[anciendaze]

Here's another article for laypeople on this research in The Atlantic. For those who don't follow scientific literature, I want to emphasize that progress from a mouse model to imaging the system in humans has taken place at remarkable speed. Normally you might have a decade of argument about whether or not it was even worth looking for this because most medical doctors believed they knew it did not exist.

With this demonstrated level of prior ignorance, I think the entire classification of functional mental illness and medically-unexplained symptoms ought to be reconsidered from the ground up.

 

[Binkie4]

@Never Give Up

Thank you for posting the article about the lymph system and the brain. I hope you will excuse me taking it off track a bit.

I recently found out via a lymphoscintigraph ( in which dye was injected into the foot between the toes in a similar way to the injection of dye in the brain in the article) that my lymph system in my lower legs is functionally highly reduced. There is very little lymph flowing and since it is the sewer system for the body, I have wondered whether the lymphedema has had any contribution to the development of ME. If my body is not disposing of its rubbish, what effect will that be having?

Unfortunately lymphedema is also hugely underresearched like ME, but if anyone has any further thoughts in this, I would be glad to read them. Thanks.

 

[NelliePledge]

@Never Give Up

Thank you for posting the article about the lymph system and the brain. I hope you will excuse me taking it off track a bit.

I recently found out via a lymphoscintigraph ( in which dye was injected into the foot between the toes in a similar way to the injection of dye in the brain in the article) that my lymph system in my lower legs is functionally highly reduced. There is very little lymph flowing and since it is the sewer system for the body, I have wondered whether the lymphedema has had any contribution to the development of ME. If my body is not disposing of its rubbish, what effect will that be having?

Unfortunately lymphedema is also hugely underresearched like ME, but if anyone has any further thoughts in this, I would be glad to read them. Thanks.

Hi people have mixed views about Raymond Perrin from what I've seen on PR about his approach but he uses lymphatic drainage on the chest and neck to relieve ME symptoms. The sessions I had from a Perrin therapist didn't involve anything with the legs. There isn't much info on his website so you have to buy his book which is annoying. But as I've had issues with swollen glands in my neck I thought it would be a good thing to try. I couldn't keep up the programme of twice daily massages as I found it too much and my skin is sensitive. I do feel that having a sluggish lymph system May be playing a role.

 

[Binkie4]

Thanks @NelliePledge

When I was diagnosed I had 10 sessions of lymphatic massage from a Vodder trained therapist. It didn't help. I haven't looked at Perrin but I will.

In the meantime I have a compression machine which massages the body in sections to move the lymph. Supposed to use it 1 hour a day but it takes energy so sometimes missed. Life feels like constant treatment! Good luck with your efforts. I agree that somehow seems reasonable to think that lymph might be involved in all this.

 

[Ecoclimber]

Sunday, 8 October 2017

Brain Drain Pipes: A waste removal system or the immune activating pathway

There are some in the ME/CFS medical field that believe ME/CFS is 'MS Light' or 'Atypical MS'. The reason I post these articles is the fact that research in one area may spill over into another area of research or the fact that researchers reviewing a site may look at the research in another disease category that could be related to theirs and it might raise their interest level.
hr
Futhermore, research may be further ahead in another field that ME/CFS researchers wish to explore if they had the funding and the researchers to explore such as EBV, HERVs, Autoimmune diseases, Fibromyalgia, Lyme etc as a B-Cell mediated diseas


Gavin Giovannoni is shifting the paradigm after 80-90 decades that it is a B-Cell mediated disease
Permission to post Prof.


Sunday, 8 October 2017

Brain Drain Pipes: A waste removal system or the immune activating pathway

As you know I have been moaning about the Late Breaking abstracts selection at ECTRIMS2017, yep sour grapes:-(...as our paper wasn't selected for a talk:-(

We will report on how and why cladribine works

Luckily (for them) our cladribine poster on effects on lymphocytes is not next to the company sponsored poster. Wonder what they will say? But as my alemtuzumab poster in next to it, I'll get hear.

But as for the rest of the late breakers we have many where the results are announced, so if you are pressed for time you can get home early.

1. We have the Fingolimod trial in children.....It worked (CLICK HERE)


2. We have anti retro virus trial...It failed at 6 months (CLICK HERE) but then it worked at 6 months (CLICK HERE)! It Treats HERV-W & MSRV


3. The ozanimod (Fingolimod me-too) trial.... It worked (CLICK HERE)

4. Are neurofilaments a biomarker for trials? My guess is Yes

5. We have pathogenic antibodies to MOG, which we are not sure if this is that important to all or only a subset of MS

6. Looking forward to the MS sprint progressive trial but no announcement from Medicinova...except that enrollment was completed in Sept and results expected 2018 (CLICK). But then they say "Dr. Fox will present the top line safety, tolerability and efficacy data of ibudilast in progressive MS".

7. Then there was the last one imaging lymphatics in primates, I thought who is interested in monkey brains?

Anyway we don't have to wait for ECTRIMS and glad to see that humans are imaged and so it is clear we have drainpipes from the brain. These will take stuff into the lymph glands.

Absinta M, Ha SK, Nair G, Sati P, Luciano NJ, Palisoc M, Louveau A, Zaghloul KA, Pittaluga S, Kipnis J, Reich DS. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. Elife. 2017 Oct 3;6. pii: e29738. doi: 10.7554/eLife.29738.

Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent (Gadofosveset binds reversibly to serum albumin, increasing its molecular weight from 0.9 to 67 kDa. Under physiological conditions, albumin has a low transcapillary exchange rate into the interstitial compartment, estimated to be on the order of 5% per hour, which explains the propensity of gadofosveset to remain within blood vessels). The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, meningeal lymphatics display a typical panel of lymphatic endothelial markers by immunohistochemistry. This discovery holds promise for better understanding the normal physiology of lymphatic drainage from the central nervous system and potential aberrations in neurological diseases.
So we know that there is lymphatic type drainage in rodents and the presence of glymphatics and not it is evident that there are drainage pathways from the brain. It means that proteins can move from the brain to the node.
If you are interested in reading the brain drainage system has been known for some time, so you can even read about the glymphatics

However in the study they could not prove whether lymphatic vessels drain immune cells, CSF, or other substances from the brain to deep cervical lymph nodes, nor could we assess any link with the glymphatic system
There is a neat video if you follow the link to the paper, so the next question is where does the spinal cord drain to? I suppose I can ask this at ECTRIMS20

Posted by MouseDoctor at 07:00
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3 comments:

1. 
   
   AnonymousSunday, October 08, 2017 4:41:00 pm
   Could apoptosis related problems / impairment in this mechanism (like in lupus) be found there? I guess this is something to check...
   Reply
2. 
   
   Nissan GrifterSunday, October 08, 2017 6:07:00 pm
   How do you think a blocked glymphatic system would effect the brain MD? How does this relate to MS or other neurodegenerative disorders? Doesn't all lymphatics eventually drain into veins?
   Reply
   Replies
   1. • 
        
        MouseDoctorSunday, October 08, 2017 8:26:00 pm
        I don't know that they block. The lymphatics drain into lymph glands and do eventually go into blood
      Reply

 

[Seven7]

I get random bump on my head right about where the lymph are. I wonder if that is what I have been feeling all this time. Since my imflamtion have been better, the bumps have been better too.
Am I the only one that that happens to?
I did have one in the top forehead tough.