Jesse2233
Senior Member
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@Learner1 has been mentioning the benefits she receives from Poly-MVA. It's something I'm eager to try, and I thought it deserved its own thread.
Has anyone else experienced benefit from it or have comments on its mechanism of action?
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Poly-MVA is a patented dietary supplement which contains palladium lipoic acid (PdLA). It is available in both IV and oral form.
Dr Paul Anderson of Bastyr University has observed QOL improvement in CFS patients after 6 weeks(1), and Dr Gary Blick has found that it decreases fatigue in HIV patients.(2)
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On its mechanism of action:
It selectively modulates pyruvate dehydrogenase in cancer cells (3)
It increases production of acetyl CoA (4)
And it boosts crucial Kreb cycle enzymes (5)
Has anyone else experienced benefit from it or have comments on its mechanism of action?
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Poly-MVA is a patented dietary supplement which contains palladium lipoic acid (PdLA). It is available in both IV and oral form.
Dr Paul Anderson of Bastyr University has observed QOL improvement in CFS patients after 6 weeks(1), and Dr Gary Blick has found that it decreases fatigue in HIV patients.(2)
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On its mechanism of action:
It selectively modulates pyruvate dehydrogenase in cancer cells (3)
Another hypothesized mechanism of action is that LAPd can target tumor cells selectively by modulating pyruvate dehydrogenase (PDH). PDH is the bridge between anaerobic and aerobic metabolism. During anaerobic metabolism, glucose is broken down to pyruvate which nets 2 ATPs. The pyruvate molecule is then channeled into aerobic metabolism. Cellular metabolism results in the generation of 38 ATPs. Because 2 ATPs are needed to initiate glycolysis, each glucose molecule will net 36 ATPs. Thus the vast majority of ATPs are generated during aerobic metabolism.
Without PDH, aerobic metabolism cannot take place and the cells shift primarily to an aerobic metabolism. While PDH activity is altered in cancer cells, LAPd may also affect it. This would eliminate the primary means of ATP production in tumor cells (aerobic metabolism) and in doing so effectively kill cancer cells.
It increases production of acetyl CoA (4)
The LAPd complex was demonstrated, by Dr. Garnett, to shuttle electrons to oxidized DNA, however, this energy flow does not appear to proceed directly to DNA. By conducting a competition assay with lipoic acid, which works at complex I of the mitochondria as a cofactor as pyruvate is converted to acetyl CoA, one can attenuate the beneficial effects.
And it boosts crucial Kreb cycle enzymes (5)
POLY-MVA was evaluated on the activities of the Krebs cycle enzymes such as isocitrate dehydrogenase, a-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase as well as mitochondrial complexes I, II, III, and IV in heart mitochondria of aged male albino rats of Wistar strain. Administration of 0.05 ml/kg of POLY-MVA (which is equivalent to 0.38 mg complexed a-lipoic acid/kg, p.o), once daily for 30 days, was significantly (p < 0.05) effective to enhance the Krebs cycle dehydrogenases, and
mitochondrial electron transport chain complexes.