Apologies, I have moved it to PM.This is thread about treating anxiety disorder, please keep to the topic.
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Apologies, I have moved it to PM.This is thread about treating anxiety disorder, please keep to the topic.
it is an oral spray not a body spray- can you image? "You know when you've been Tangoed"
Hey hip. I'm on a regimen of 75mg nortriptyline, 40mg lexapro and 80mg atOmoxetine for depression and ADHD. I want to add 10mg amiloride to the regimen but the leaflet says it's not recommended to take it with tricyclics or atomoxetine. It also says to avoid anti-psychotics. Was wondering whether I could just ignore the precautions and take it anyway?Should be fine.
similar to you, anxiety, depression and denationalization. a comibination of two nri's and one ssri helps and am curious to know whether amiloride will increase the efficacy or improve the combination. any notable cognitive improvements since restarting it? i also feel complete remission from a hangover and am wondering if there's a glutaminergic element to the problem. considering trying ketamine. i'm also very sensetive to norepinephrine, running and cold showers severely disturb my cognition.Hi @sugamama, according to the interactions checker at drugs.com, the interaction between nortriptyline and amiloride is a moderate one (not a major one), which may lead to some lowered blood pressure.
Any particular reason for taking amiloride?
Do you have any dopamine related issues?
@Hip I'm curious about something, I've been doing some reading on NAG and ordered some from Jarrow to give it a try.
Do you have any dopamine related issues? Specifically ANKK1 A1? Or general (DDD) Dopamine Deficient Depression?
I came across a study where they used GlcNAc to clean D2 receptors from Bovine to sample.
"Under optimal conditions about 65% of the applied D2 dopamine receptors bound to WGA-agarose and could be eluted with N-acetylglucosamine."
They determined D2 receptors were glycoproteins as a result. I haven't had a chance to dive into it, and studies and few and far between.
No offense but I wish when people make posts like this they could explain it in more detail, this is about as vague as vague can be. Is this saying that NAG obliterates dopamine receptors? as far as I can tell "eluted" means to clean or remove. Or is it saying it resets them and therefore would help dopamine production?
Ive tried searching google and cant find much of anything. Curious as Im taking NAG as part of a gut protocol.
I came across a study where they used GlcNAc to clean D2 receptors from Bovine to sample.
"Under optimal conditions about 65% of the applied D2 dopamine receptors bound to WGA-agarose and could be eluted with N-acetylglucosamine."
No offense but I wish when people make posts like this they could explain it in more detail, this is about as vague as vague can be. Is this saying that NAG obliterates dopamine receptors? as far as I can tell "eluted" means to clean or remove. Or is it saying it resets them and therefore would help dopamine production?
D2 receptors are n linked glycoproteins. WGA-Agglutinin comes from wheat, corn, oats etc, it crosses the blood brain barrier and has affinity with several dopaminergic systems.
Small amounts of WGA are very pro-inflammatory. WGA can form a glycoprotein with NAG which causes even more damage.
In the study they used NAG to remove WGA from the receptors.