Esther12
Senior Member
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Not really important, but I just noticed this. The 'independent' oversight of the PACE trial seemed to come almost entirely from those sharing the PI's ideological positions, which may explain why it was so careless.
https://www.britishinfection.org/files/1515/0093/2785/BIA_-_May_2017_-_Abstract_Book.pdf
BRITISH INFECTION ASSOCIATION
Session 3:
Dr Meirion Llewellyn
Consultant in Infectious Diseases
Royal Gwent Hospital
Dr Meirion Llewelyn BSc FRCP PhD qualified in Medicine in Cardiff and trained at Hammersmith and St Thomas’ Hospitals in London. He was registrar in Infectious Diseases at Addenbrooke’s hospital Cambridge, then MRC fellow at the Laboratory of Molecular Biology and Harrison-Watson Student at Clare College Cambridge. He returned to Cardiff as Senior Registrar in Infectious Diseases and is Consultant Physician in Medicine/Infectious Diseases at The Royal Gwent Hospital. Recent research interests have included diagnostic methods for chronic Q Fever and treatment approaches to medically unexplained syndromes.
Difficult symptoms in the ID clinic Medically unexplained symptoms (MUS) are troubling physical symptoms for which no organic pathology can be found. These unexplained symptoms are very common in all branches of medicine, forming nearly one third of cases in hospital outpatient clinics. Although these are epidemiologically related to depression and anxiety, they do not appear to represent a primary mood disorder. Because infectious mononucleosis can be followed by either excessive sleep or insomnia associated with muscle and joint pain, (with psychomotor retardation and poor concentration in both), many patients with medically unexplained symptoms are referred to Infectious Diseases Clinics. The vast majority of these will have no infectious aetiology for their problem and present with the typical symptoms of neurasthenia, first described in 1869. The symptoms of neurasthenia include exhaustion, widespread musculoskeletal pain, impairment of cognitive function, post exertional malaise and unrefreshing sleep. The list of symptoms often approaches 30 and they are often written in a list, a syndrome called by Charcot ‘
la maladie du petit papier’.
A minority of patients with neurasthenic symptoms also have disease convictions and these have included entities such as ‘Chronic Candidal infection’, ‘seronegative Lyme disease’ and ‘multiple chemical sensitivity’.
Understanding the now forgotten symptoms of neurasthenia can shed light on the vast majority of patients with medically unexplained symptoms in the ID Clinic, and illustrate that persistence of symptoms now delineated as chronic fatigue syndrome or fibromyalgia throughout history.
https://www.britishinfection.org/files/1515/0093/2785/BIA_-_May_2017_-_Abstract_Book.pdf